Omeros (OMER.US) Stock Rating 2026/2027: Buy – Stock Analysis

19.63
Share this analysis:

No analysts currently cover Omeros with a public price target. We add the price target automatically as soon as at least one analyst publishes a rating. Until then, use the technical analysis and the key figures below.

Analyst Ratings for Omeros stock in 2026: Buy

3 analysts cover Omeros. The majority is positive, with 66.7% recommending Buy, while 33.3% recommend Hold.

Consensus: Buy (4.33/5)
Strong Buy
2 (66.7%)
Hold
1 (33.3%)
Strong Sell Sell Hold Buy Strong Buy
4.33 out of 5 based on 3 analysts

About Omeros – Biotechnology

Omeros Corporation, a clinical-stage biopharmaceutical company, discovers, develops, and commercializes small-molecule and protein therapeutics, and orphan indications targeting immunologic diseases. The company's lead products candidate is the Narsoplimab (OMS721/MASP-2) for the treatment of hematopoietic stem-cell transplant-associated thrombotic microangiopathy (TA-TMA); and in Phase II clinical trial to treat COVID-19 and acute respiratory distress syndrome. It also develops OMS1029 that has completed phase I clinical trials for mannan-binding lectin-associated serine protease 2 (MASP-2) and lectin pathway disorders; and OMS527 that is in phase I clinical trials for addictions and compulsive disorders, and movement disorders, as well as cocaine use disorder. In addition, the company's products under preclinical development comprise MASP-2, a pro-inflammatory protein target for the treatment of lectin pathway disorders; MASP-3 small-molecule inhibitors for alternative pathway disorders; OncotoX-AML, to treat acute myeloid leukemia; and Targeted Complement Activating Therapy, for Multidrug-resistant organisms. Omeros Corporation was incorporated in 1994 and is headquartered in Seattle, Washington. Read more about the company

Key Figures for Omeros

$1.4B Market cap
$38.4M Revenue
Biotechnology Industry
16.25 P/E
37.36 P/S
8.44 P/B
United States Listed on exchange
omeros.com Website

What kind of stock is Omeros?

Momentum stock

Omeros is classified as a momentum stock with a momentum score in the top 4% of all stocks. The price has risen 0.0% over the long term.

Score Overview for Omeros

💰 Value Score 43/100 (Neutral)
⭐ Quality Score 100/100 (Very High)
🚀 Momentum Score 96/100 (Very High)
📊 Total Score 79/100

⚠️ 4 red flags identified 3 critical

Our analysis has identified 4 potential risk factors in Omeros that investors should be aware of.

🚨 High debt: The debt-to-equity ratio is 1,000% – the company carries considerably more debt than equity, which raises the financial risk.
🚨 Weak balance sheet (elevated risk): Altman Z2 is -4.60 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative return on equity: ROE is -576.3% – the company is generating a negative return for shareholders.
⚠️ High short interest: 17.9% of the shares are sold short – many professional investors are betting on price declines.

📈 Valuation

Omeros trades at a P/E ratio of 16.3, which is close to the market average. The forward P/E is 87.7. The P/S ratio is 37.4 (high — the market pays a premium for the revenue). The P/B ratio is 8.4. The PEG ratio is 0.81 — below 1.0 suggests the stock is cheap relative to its growth rate.

💵 Profitability & Growth

Omeros has a profit margin of 324.9% (excellent) and an operating margin of 0.3%.

🏦 Financial Health

The Piotroski score is 6 out of 9 — good financial health. Altman Z2 is -4.60 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 1,000.0% — high debt, which raises the risk.

🚀 Momentum & Short Interest

Short interest is 17.89% — very high, the market is skeptical.

Insider Trading in Omeros 2026: The Signal Is negative

In 2026, insiders at Omeros have made 17 transactions – split into 2 purchases and 15 sales. On a net basis, insiders took $2,598,973 out of the stock. Active insiders include Demopulos Gregory A MD, Demopulos Peter A MD, Borges David J. and others. In the short term (last 3 months), the insider signal is negative.

Short-Term Signal (3 months): Negative

Insiders have exclusively sold shares over the last 3 months.

Over the last 3 months: 0 purchases and 10 sales. A net $1,736,548 out of the stock.

Long-Term Signal (all transactions): Mostly negative

Insiders have sold considerably more than they have bought. At large companies this can be due to planned sales (10b5-1 plans) and is not necessarily a negative signal.

Across the last 17 transactions: 2 purchases and 15 sales. A net $2,598,973 out of the stock.

Latest purchase: Demopulos Gregory A MD bought 15,000 shares at $1.68 each on 2023-11-17. The stock has since risen 1068.5%.

Latest sale: Borges David J. sold 10,000 shares at $20.95 each on 2026-09-23.

Who is buying: Demopulos Gregory A MD, Demopulos Peter A MD.

Who is selling: Borges David J., Cancelmo Peter B, HANISH ARNOLD C, Cable Thomas J..

Latest Insider Trades in Omeros (2026)

The table shows the last 17 reported insider transactions in Omeros. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-09-23 Borges David J. Sell 10,000 21 209,500
2026-09-22 Borges David J. Sell 5,000 21 104,750
2026-08-31 Cancelmo Peter B Sell 25,000 19 463,500
2026-08-28 Cancelmo Peter B Sell 25,000 19 466,250
2026-08-27 HANISH ARNOLD C Sell 2,500 19 47,550
2026-08-26 HANISH ARNOLD C Sell 5,000 19 92,650
2026-08-24 Borges David J. Sell 906 19 17,305
2026-08-21 Borges David J. Sell 5,906 19 111,919
2026-08-20 Cable Thomas J. Sell 7,500 18 138,375
2026-08-13 Borges David J. Sell 5,000 17 84,750

Who is buying and selling Omeros shares in 2026?

The following insiders have bought shares in Omeros: Demopulos Gregory A MD, Demopulos Peter A MD. In total, $40,500 was bought across 2 transactions. The following insiders have sold shares: Borges David J., Cancelmo Peter B, HANISH ARNOLD C, Cable Thomas J.. In total, $2,639,473 was sold across 15 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Omeros Short Selling 2026: 17.9% Sold Short

Very high short interest: 17.9% of the free float
Short % of free float
17.9%
Assessment
Very high short interest
Short squeeze risk
High
Data source
EODHD
Reported about twice a month
The stock has a very high share of short selling. Between 10-20% of the freely traded shares are sold short, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains.

What does this mean for you as an investor?
A short interest of 17.9% means that 17.9% of the freely traded shares in Omeros have been borrowed and sold by investors betting on falling prices. On positive surprises (e.g. a strong earnings report), short sellers can be forced to buy back shares quickly to close their positions, which can cause a short squeeze with sharp price gains in a short time.

The next potential catalyst is the earnings report on Nov 12, 2026. With a short interest of 17.9%, the report can trigger considerable volatility.

Short interest comes from our data provider EODHD. The figure is reported about twice a month; we check it every trading day.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
▲
17.9%

When Does Omeros Report Earnings – Next Date: Nov 12, 2026

The next earnings report from Omeros is scheduled for November 12, 2026, after the market closes. This report covers the third quarter (Q3), which ended on September 30, 2026.



Technical Analysis of Omeros 2026 – Signal: Strong Buy

Overall Technical Signal: Strong Buy

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated October 13, 2026.

Trend Analysis of Omeros Corporation

Omeros Corporation is in a short-term uptrend. The price of $19.63 is 3.1% above the 20-day average ($19.04). Medium term, the picture is positive: the price is 9.8% above the 50-day average ($17.87). Long term, the stock is 47.6% above the 200-day average ($13.30), which confirms a long-term uptrend.

Golden Cross: The 50-day average (17.87) is above the 200-day average (13.30), which is a classic bullish signal for Omeros Corporation.

Is Omeros Corporation overbought or oversold?

Omeros Corporation has an RSI of 57.8. The stock shows positive momentum in the upper part of the neutral zone. Combined with the positive trend, this supports the bullish picture.

MACD Analysis for Omeros Corporation

Daily MACD: MACD is positive (0.415), which means the short-term trend is bullish (the 12-day EMA is above the 26-day EMA). MACD is below the signal line (0.499) by 0.084, which suggests the positive momentum is fading – the trend could be turning.

Weekly MACD: MACD5 is positive (2.275), which indicates a broader bullish long-term trend. MACD5 is above the signal line (1.667) by 0.608, which confirms rising long-term momentum.

Overall MACD assessment: Both the daily and weekly trend are bullish (MACD positive). However, momentum shows signs of weakening on a daily basis. Watch whether the trend holds.

Risk Profile for Omeros Corporation

Omeros Corporation has an annual standard deviation of 0.0%, which classifies the stock as Conservative. Price swings are limited, and the stock suits conservative investors.

Overall Technical Conclusion for Omeros Corporation

Trend: Positive. The price trades above SMA50 and SMA200.

MACD trend (zero line): Daily bullish (0.415). Weekly bullish (2.275).

MACD momentum (signal): Daily falling. Weekly rising.

RSI: 57.8 – neutral.

Technical signal: Strong Buy

The price is in an uptrend (above SMA50/SMA200) and MACD is positive on both a daily and weekly basis. Trend and MACD trend confirm each other – the strongest technical buy signal.

Frequently Asked Questions About Omeros stock in 2026

Should you buy Omeros stock now?
Yes, the technical signal for Omeros is currently Strong Buy. Omeros trades at $19.63 as of Oct 13, 2026. The technical analysis shows the following: MACD is positive (bullish trend) at 0.415 with falling momentum (signal: 0.499); RSI is at 57.8 (neutral zone); the stock is in a short-term uptrend (price above the 20-day average). The stock is in a broader uptrend (above SMA50/SMA200). This is a technical observation based on current data, not investment advice.
What is the price target for Omeros stock?
There is currently no active analyst price target for Omeros.
Is Omeros a dividend stock?
No, Omeros does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Omeros stock?
Omeros is rated as a stock in the risk category Conservative. the annual standard deviation is 0.0%, which classifies the stock as Conservative.
Is Omeros overvalued?
Omeros has the following valuation ratios: a P/E ratio of 16.3 (moderately valued), a P/S ratio of 37.4, a P/B ratio of 8.4.
Is Omeros overbought?
No, Omeros is not overbought. RSI is at 57.8 (neutral zone). The technical indicators show: RSI is at 57.8 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 3.1% above the 20-day average (short-term uptrend). In addition, MACD is positive, but momentum is falling.
When is the next Omeros earnings report?
Omeros reports its next earnings on November 12, 2026. The stock currently trades at $19.63. With a P/E ratio of 16.3, the market will be watching closely whether earnings meet expectations.
Is Omeros shorted?
Yes, Omeros is shorted with 17.9% of the free float sold short. This is a very high level of short selling, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains. The figure comes from our data provider EODHD, is reported about twice a month, and we check it every trading day.
Are insiders buying Omeros stock?
No, insiders are not buying Omeros shares – they are net sellers. Over the last 3 months, insiders have made 0 purchases and 10 sales. On a net basis, 1,736,548 $ worth of shares were sold. Across the last 17 reported transactions, the split is 2 purchases and 15 sales, with a net 2,598,973 $ sold. Active sellers include Borges David J., Cancelmo Peter B, HANISH ARNOLD C and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Omeros a good stock?
Based on our total score, Omeros is rated as a good stock with a total score of 79 out of 100. The stock scores above average on value, quality and momentum. The score is made up of Value: 43/100, Quality: 100/100, Momentum: 96/100. Whether now is the time to buy is a separate question: the technical signal is Strong Buy. Whether Omeros is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Omeros stock?
The outlook for Omeros based on current data: the stock is in an uptrend (above SMA50 and SMA200); the next earnings report is due on Nov 12, 2026, which can move the price; the P/E ratio is 16.3 (moderate). Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Omeros stock rising?
Omeros is rising right now. The technical indicators show: the price is 3.1% above the 20-day average; short interest is 17.9% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis and insider section above.
How high can Omeros go?
There is currently no active analyst price target for Omeros. The stock has traded between $4.06 and $21.24 over the last 52 weeks. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Omeros fall?
The stock has traded as low as $4.06 over the last 52 weeks — that is 79.3% below the current price of $19.63. The biggest decline (drawdown) in the same period was 80.9% from high to low. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Omeros do?
Omeros Corporation, a clinical-stage biopharmaceutical company, discovers, develops, and commercializes small-molecule and protein therapeutics, and orphan indications targeting immunologic diseases. The company's lead products candidate is the Narsoplimab (OMS721/MASP-2) for ... The company belongs to the Healthcare sector, more specifically the Biotechnology industry, is headquartered in United States, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Omeros as an investment.
Did Omeros raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Omeros. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history above.
Is Omeros making money or losing money?
Yes, Omeros is making money, not losing it. The company has a profit margin (the share of revenue left over as profit) of 324.9% — which is excellent. The operating margin (profit before interest and taxes) is 0.3%. At a P/E ratio of 16.3, you currently pay 16.3 dollars for every dollar of the company's annual earnings. A consistently profitable company is usually more resilient than growth stocks that are not yet making money.
Can Omeros go bankrupt?
The bankruptcy risk of Omeros is rated as elevated. Altman Z2 (a model for assessing financial distress) is -4.60 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. The Piotroski score (financial health 0-9, higher is better) is 6 — which is average. Debt relative to equity is 1,000% (high). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Omeros have a lot of debt?
Yes, Omeros has elevated debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 1,000%. For the healthcare sector, anything above 150% counts as elevated — that raises the financial risk, especially if interest rates rise or earnings fall. In healthcare, 80-150% is typical — large pharma companies carry debt for research and acquisitions. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.