Inovio Pharmaceuticals (INO.US) Price Target 2026/2027: 180% Upside – Rating and Stock Analysis

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Price history for Inovio Pharmaceuticals (INO.US) – stock price at $1.13, October 2026
Inovio Pharmaceuticals stock price – price development 2026. Updated Oct 7, 2026.
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Inovio Pharmaceuticals Price Target 2026: Analysts See 181% Upside

The average price target for Inovio Pharmaceuticals is $3.17. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 180.53% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is Inovio Pharmaceuticals overvalued or undervalued?

Inovio Pharmaceuticals is currently undervalued with a gap of 180.5% relative to the price target.


The current price is $1.13, which places Inovio Pharmaceuticals in the undervalued category. The stock is considered undervalued when the price is below $2.85, and overvalued when the price exceeds $3.49.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Inovio Pharmaceuticals, the fair value range lies between $2.85 and $3.49.


See the full price target analysis for Inovio Pharmaceuticals →

Analyst Ratings for Inovio Pharmaceuticals stock in 2026: Buy

3 analysts cover Inovio Pharmaceuticals. The majority is positive, with 66.6% recommending Buy, while 33.3% recommend Hold. The average price target is $3.17, which gives an upside of 180.5% from the current price.

Consensus: Buy (4.00/5)
Strong Buy
1 (33.3%)
Buy
1 (33.3%)
Hold
1 (33.3%)
Strong Sell Sell Hold Buy Strong Buy
4.00 out of 5 based on 3 analysts

About Inovio Pharmaceuticals – Biotechnology

Inovio Pharmaceuticals develops DNA-based medicines. These are designed to treat diseases linked to HPV (a common virus), cancer, and infections. The company makes money by researching and selling these medicines, which it creates using its own method called SynCon technology. To get the medicine into a patient's body, Inovio uses devices it developed itself, called CELLECTRA.

The company runs clinical trials, which are tests on patients to check if a medicine works and is safe. These trials focus on early-stage cancer conditions, such as the kind that can lead to cervical cancer, as well as infections like Ebola and MERS. Inovio has many projects in development at different stages, often referred to as its pipeline.

Inovio works together with partner companies, including AstraZeneca and ApolloBio Corp, to develop and bring its medicines forward. The company was founded in 1983 and has focused on this type of DNA-based medicine ever since.
Read more about the company

Key Figures for Inovio Pharmaceuticals

$120M Market cap
- Revenue
Biotechnology Industry
- P/E
961.51 P/S
30.51 P/B
United States Listed on exchange
inovio.com Website

What kind of stock is Inovio Pharmaceuticals?

Speculative stock

Inovio Pharmaceuticals is classified as a speculative stock.

Score Overview for Inovio Pharmaceuticals

💰 Value Score 2/100 (Very Low)
⭐ Quality Score 3/100 (Very Low)
🚀 Momentum Score 14/100 (Very Low)
📊 Total Score 6/100

⚠️ 3 red flags identified 3 critical

Our analysis has identified 3 potential risk factors in Inovio Pharmaceuticals that investors should be aware of.

🚨 Weak balance sheet (elevated risk): Altman Z2 is -130.58 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative return on equity: ROE is -409.9% – the company is generating a negative return for shareholders.
🚨 High short interest: 21.4% of the shares are sold short – many professional investors are betting on price declines.

📈 Valuation

The P/S ratio is 961.5 (high — the market pays a premium for the revenue). The P/B ratio is 30.5.

🏦 Financial Health

Altman Z2 is -130.58 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 65.2% — low debt, a solid balance sheet.

🚀 Momentum & Short Interest

Short interest is 21.37% — very high, the market is skeptical.

Insider Trading in Inovio Pharmaceuticals 2026: The Signal Is negative

In 2026, insiders at Inovio Pharmaceuticals have made 20 transactions, all of which were sales. On a net basis, insiders took $310,324 out of the stock. Active insiders include Zoth Lota S., Weiner David B., David B Weiner and others.

Short-Term Signal (3 months): No activity

There has been no insider trading in the last 3 months.

Long-Term Signal (all transactions): Negative

Insiders have exclusively sold shares in the recent period. This can suggest management sees limited opportunity.

Across the last 20 transactions: 0 purchases and 20 sales. A net $310,324 out of the stock.

Latest sale: Zoth Lota S. sold 5,700 shares at $0.56 each on 2023-06-05.

Who is selling: Zoth Lota S., Weiner David B., David B Weiner, Simon X Benito, BENITO SIMON X and others.

Latest Insider Trades in Inovio Pharmaceuticals (2026)

The table shows the last 20 reported insider transactions in Inovio Pharmaceuticals. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2023-06-05 Zoth Lota S. Sell 5,700 1 3,192
2023-03-13 Weiner David B. Sell 5,833 1 6,708
2023-03-13 David B Weiner Sell 40 166 6,624
2023-02-27 Weiner David B. Sell 11,668 1 14,935
2023-02-27 David B Weiner Sell 81 184 14,930
2022-08-11 Weiner David B. Sell 11,875 3 31,588
2022-08-11 David B Weiner Sell 82 383 31,409
2022-07-20 Simon X Benito Sell 13 324 4,212
2022-07-20 BENITO SIMON X Sell 2,000 2 4,500
2022-05-16 Zoth Lota S. Sell 3,600 2 7,128

Who is buying and selling Inovio Pharmaceuticals shares in 2026?

The following insiders have sold shares: Zoth Lota S., Weiner David B., David B Weiner, Simon X Benito, BENITO SIMON X and others. In total, $310,324 was sold across 20 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Inovio Pharmaceuticals Short Selling 2026: 21.4% Sold Short

Extremely shorted: 21.4% of the free float
Short % of free float
21.4%
Assessment
Extremely shorted
Short squeeze risk
Very High
Data source
EODHD
Reported about twice a month

Short interest over time: Inovio Pharmaceuticals

0.0%13.0%26.0%
Peak 22.6% · 6/11
5/307/299/27
21.4% today (extremely high)Peaked at 22.6% on Jun 11, 2026Essentially unchanged over the last 30 daysMeasured over 120 days
What does the trend tell you?
Short interest in Inovio Pharmaceuticals has been fairly stable at 21.4% over the period. Neither many new short sellers have arrived nor many positions been closed.

What matters is when the curve starts to move. This is how shorting works: whoever shorts has borrowed the share and sold it, and to close the position again they must buy the share back. When short interest falls, shares are being bought back. So it is worth watching the trend, not just today's number.
The stock has an extremely high share of short selling. More than 20% of the freely traded shares are sold short, which is unusual and can point to great skepticism among institutional investors. The risk of a short squeeze on positive news is considerable.

What does this mean for you as an investor?
A short interest of 21.4% means that 21.4% of the freely traded shares in Inovio Pharmaceuticals have been borrowed and sold by investors betting on falling prices. On positive surprises (e.g. a strong earnings report), short sellers can be forced to buy back shares quickly to close their positions, which can cause a short squeeze with sharp price gains in a short time.

The next potential catalyst is the earnings report on Nov 9, 2026. With a short interest of 21.4%, the report can trigger considerable volatility.

Short interest comes from our data provider EODHD. The figure is reported about twice a month; we check it every trading day.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
▲
21.4%

When Does Inovio Pharmaceuticals Report Earnings – Next Date: Nov 9, 2026

The next earnings report from Inovio Pharmaceuticals is scheduled for November 9, 2026. This report covers the third quarter (Q3), which ended on September 30, 2026.



Technical Analysis of Inovio Pharmaceuticals 2026 – Signal: Sell

Overall Technical Signal: Sell

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated October 7, 2026.

Technical analysis of Inovio Pharmaceuticals (INO.US) – RSI 44, MACD negative (bearish), daily candlestick chart October 2026
Inovio Pharmaceuticals technical analysis – candlestick chart with RSI, MACD and volume profile. Updated Oct 7, 2026.

Trend Analysis of Inovio Pharmaceuticals, Inc

Inovio Pharmaceuticals, Inc is in a short-term downtrend. The price of $1.13 is 6.3% below the 20-day average ($1.21). Medium term, the picture is positive: the price is 1.3% above the 50-day average ($1.12). Long term, the stock is 15.9% below the 200-day average ($1.34), which signals a long-term downtrend.

Death Cross: The 50-day average (1.12) is below the 200-day average (1.34), which is a classic bearish signal for Inovio Pharmaceuticals, Inc.

Is Inovio Pharmaceuticals, Inc overbought or oversold?

Inovio Pharmaceuticals, Inc has an RSI of 43.9. The stock sits in the lower part of the neutral zone, which points to weak momentum without being oversold.

MACD Analysis for Inovio Pharmaceuticals, Inc

Daily MACD: MACD is negative (-0.009), which means the short-term trend is bearish (the 12-day EMA is below the 26-day EMA). MACD is below the signal line (0.006) by 0.015, which confirms growing negative momentum in the downtrend.

Weekly MACD: MACD5 is negative (-0.075), which indicates a broader bearish long-term trend. MACD5 is above the signal line (-0.125) by 0.050, which suggests the negative long-term momentum is fading – a bigger trend reversal could be ahead.

Overall MACD assessment: Both the daily and weekly trend are bearish (MACD negative). However, momentum shows signs of improving on a weekly basis – a potential trend reversal could be ahead, but it is not confirmed yet.

Risk Profile for Inovio Pharmaceuticals, Inc

Inovio Pharmaceuticals, Inc has an annual standard deviation of 87.1%, which classifies the stock as Extremely speculative. Only risk-tolerant investors should consider this stock, because the price swings can be very large.

Overall Technical Conclusion for Inovio Pharmaceuticals, Inc

Trend: Neutral/mixed.

MACD trend (zero line): Daily bearish (-0.009). Weekly bearish (-0.075).

MACD momentum (signal): Daily falling. Weekly rising.

RSI: 43.9 – neutral.

Technical signal: Sell

The trend is negative and MACD is below the zero line, which confirms the bearish momentum. Consider reducing the position or setting a stop-loss.

Frequently Asked Questions About Inovio Pharmaceuticals stock in 2026

Should you buy Inovio Pharmaceuticals stock now?
No, the technical signal for Inovio Pharmaceuticals is currently Sell. Inovio Pharmaceuticals trades at $1.13 as of Oct 7, 2026. The technical analysis shows the following: MACD is negative (bearish trend) at -0.009 with falling momentum (signal: 0.006); RSI is at 43.9 (neutral zone); the stock is in a short-term downtrend (price below the 20-day average); the analyst price target of $3.17 points to 180.5% upside. This is a technical observation based on current data, not investment advice.
What is the price target for Inovio Pharmaceuticals stock?
The average analyst price target for Inovio Pharmaceuticals is $3.17. The current price is $1.13, which gives an upside of 180.5%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $2.85 and $3.49.
Is Inovio Pharmaceuticals a dividend stock?
No, Inovio Pharmaceuticals does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Inovio Pharmaceuticals stock?
Inovio Pharmaceuticals is rated as a stock in the risk category Extremely speculative. the annual standard deviation is 87.1%, which classifies the stock as Extremely speculative.
Is Inovio Pharmaceuticals overvalued?
No, Inovio Pharmaceuticals is considered undervalued based on the analyst price target (180.5% upside). Inovio Pharmaceuticals has the following valuation ratios: a P/S ratio of 961.5, a P/B ratio of 30.5. The analyst price target suggests that the stock is undervalued by 180.5%.
Is Inovio Pharmaceuticals overbought?
No, Inovio Pharmaceuticals is not overbought. RSI is at 43.9 (neutral zone). The technical indicators show: RSI is at 43.9 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 6.3% below the 20-day average (short-term downtrend). In addition, MACD is negative with falling momentum (bearish).
When is the next Inovio Pharmaceuticals earnings report?
Inovio Pharmaceuticals reports its next earnings on November 9, 2026. The stock currently trades at $1.13.
Is Inovio Pharmaceuticals shorted?
Yes, Inovio Pharmaceuticals is shorted with 21.4% of the free float sold short. This is an extremely high level of short selling, which points to great skepticism among institutional investors. The risk of a short squeeze on positive news or earnings is very high. The figure comes from our data provider EODHD, is reported about twice a month, and we check it every trading day.
Are insiders buying Inovio Pharmaceuticals stock?
No, insiders are not buying Inovio Pharmaceuticals shares – they are net sellers. Across the last 20 reported transactions, the split is 0 purchases and 20 sales, with a net 310,324 $ sold. Active sellers include Zoth Lota S., Weiner David B., David B Weiner and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Inovio Pharmaceuticals a good stock?
Based on our total score, Inovio Pharmaceuticals is rated as a disastrous stock with a total score of 6 out of 100. The stock scores very low on value, quality and momentum – it is among the worst in our database. The score is made up of Value: 2/100, Quality: 3/100, Momentum: 14/100. In addition: analysts see 180.5% upside to the price target; technical signal: Sell. Whether Inovio Pharmaceuticals is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Inovio Pharmaceuticals stock?
The outlook for Inovio Pharmaceuticals based on current data: the average analyst price target is $3.17 (+180.5%); the next earnings report is due on Nov 9, 2026, which can move the price. Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Inovio Pharmaceuticals stock falling?
Inovio Pharmaceuticals is falling right now. The technical indicators show: the price is 6.3% below the 20-day average; MACD is negative with falling momentum (bearish signal); short interest is 21.4% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis and insider section above.
How high can Inovio Pharmaceuticals go?
The average analyst price target for Inovio Pharmaceuticals is $3.17, which corresponds to a potential gain of 180.5% from the current price of $1.13. The stock has traded between $0.56 and $2.72 over the last 52 weeks. The price is 58.5% below the 52-week high, which can indicate potential if the underlying fundamentals are intact. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Inovio Pharmaceuticals fall?
The stock has traded as low as $0.56 over the last 52 weeks — that is 50.4% below the current price of $1.13. The biggest decline (drawdown) in the same period was 79.4% from high to low. Within a year, the price typically swings about ±87.1% (standard deviation — a measure of price swings). A difficult year could therefore mean a further decline of that size. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Inovio Pharmaceuticals do?
Inovio Pharmaceuticals develops DNA-based medicines. These are designed to treat diseases linked to HPV (a common virus), cancer, and infections. The company makes money by researching and selling these medicines, which it creates using its own method called SynCon technology.... The company belongs to the Healthcare sector, more specifically the Biotechnology industry, is headquartered in United States, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Inovio Pharmaceuticals as an investment.
Did Inovio Pharmaceuticals raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Inovio Pharmaceuticals. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history above.
Is Inovio Pharmaceuticals making money or losing money?
We have no current profitability data for Inovio Pharmaceuticals. See the latest report in the earnings history above.
Can Inovio Pharmaceuticals go bankrupt?
The bankruptcy risk of Inovio Pharmaceuticals is rated as elevated. Altman Z2 (a model for assessing financial distress) is -130.58 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. Debt relative to equity is 65% (moderate). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Inovio Pharmaceuticals have a lot of debt?
No, Inovio Pharmaceuticals has low debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 65%. For the healthcare sector, anything below 80% counts as low debt. In healthcare, 80-150% is typical — large pharma companies carry debt for research and acquisitions. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.

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