Denali Therapeutics (DNLI.US) Price Target 2026/2027: 40% Upside – Rating and Stock Analysis

24,46
0,16%
Price history for Denali Therapeutics (DNLI.US) – stock price at 24.46 $, August 2026
Denali Therapeutics stock price – price development 2026. Updated Aug 6, 2026.
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Denali Therapeutics Price Target 2026: Analysts See 40% Upside

The average price target for Denali Therapeutics is $34.31. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 40,27% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is Denali Therapeutics overvalued or undervalued?

Denali Therapeutics is currently undervalued with a gap of 40.3% relative to the price target.


The current price is $24.46, which places Denali Therapeutics in the undervalued category. The stock is considered undervalued when the price is below $30.88, and overvalued when the price exceeds $37.74.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Denali Therapeutics, the fair value range lies between $30.88 and $37.74.


See the full price target analysis for Denali Therapeutics →

Analyst Ratings for Denali Therapeutics stock in 2026: Strong Buy

19 analysts cover Denali Therapeutics. There is broad agreement on a positive view — 100% recommend buying. The average price target is $34.31, which gives an upside of 40.3% from the current price.

Consensus: Strong Buy (4.79/5)
Strong Buy
15 (78.9%)
Buy
4 (21.1%)
Strong Sell Sell Hold Buy Strong Buy
4.79 out of 5 based on 19 analysts

About Denali Therapeutics – Bioteknologi

Denali Therapeutics laver medicin mod nervesygdomme og sjældne stofskiftesygdomme. De udvikler behandlinger, der kan trænge ind i hjernen, hvilket er ret svært. Denali fokuserer især på at få deres lægemidler frem til de steder, hvor sygdommen opstår. De har en stor pipeline med mange projekter. For eksempel arbejder de på Eclitasertib, en hæmmer til betændelsestilstande, og DNL343, som er målrettet ALS-patienter. Et andet vigtigt program er BIIB122 mod Parkinsons sygdom. Denali Therapeutics bruger også særlige transportteknologier, som deres Enzyme TransportVehicle, for at optimere effekten. Virksomheden blev grundlagt i 2015 og driver forskning i USA, men sigter globalt. Read more about the company

Key Figures for Denali Therapeutics

$ 3,9B Market cap
- Revenue
Bioteknologi Industry
- P/E
3,643.65 P/S
3.95 P/B
USA Listed on exchange
Sundhed Sector

What kind of stock is Denali Therapeutics?

Momentum stock

Denali Therapeutics is classified as a momentum stock with a momentum score in the top 19% of all stocks. The price has risen 0.0% over the long term.

Score Overview for Denali Therapeutics

💰 Value Score 10/100 (Very Low)
⭐ Quality Score 6/100 (Very Low)
🚀 Momentum Score 81/100 (Very High)
📊 Total Score 32/100

⚠️ 3 red flags identified 2 critical

Our analysis has identified 3 potential risk factors in Denali Therapeutics that investors should be aware of.

🚨 Weak balance sheet (elevated risk): Altman Z2 is -0.72 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative return on equity: ROE is -49.6% – the company is generating a negative return for shareholders.
⚠️ High short interest: 10.7% of the shares are sold short – many professional investors are betting on price declines.

📈 Valuation

The P/S ratio is 3,643.6 (high — the market pays a premium for the revenue). The P/B ratio is 3.9.

🏦 Financial Health

Altman Z2 is -0.72 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 11.8% — low debt, a solid balance sheet.

🚀 Momentum & Short Interest

Short interest is 10.66% — very high, the market is skeptical.

Insider Trading in Denali Therapeutics 2026: The Signal Is mostly negative

In 2026, insiders at Denali Therapeutics have made 20 transactions – split into 1 purchases and 19 sales. On a net basis, insiders took 17,399,670 $ out of the stock. Active insiders include Ho Carole, Watts Ryan J., Schuth Alexander O. and others.

Short-Term Signal (3 months): No activity

There has been no insider trading in the last 3 months.

Long-Term Signal (all transactions): Mostly negative

Insiders have sold considerably more than they have bought. At large companies this can be due to planned sales (10b5-1 plans) and is not necessarily a negative signal.

Across the last 20 transactions: 1 purchases and 19 sales. A net 17,399,670 $ out of the stock.

Latest purchase: Ho Carole bought 44,655 shares at 1 $ each on 2025-08-05. The stock has since risen 3491.2%.

Latest sale: Watts Ryan J. sold 35,198 shares at 17 $ each on 2026-01-06.

Who is buying: Ho Carole.

Who is selling: Watts Ryan J., Schuth Alexander O., Ryan J Watts, Alexander O Schuth, Ho Carole and others.

Latest Insider Trades in Denali Therapeutics (2026)

The table shows the last 20 reported insider transactions in Denali Therapeutics. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-01-06 Watts Ryan J. Sell 35,198 17 580,767
2026-01-06 Schuth Alexander O. Sell 17,218 17 284,097
2026-01-06 Ryan J Watts Sell 35,198 17 580,767
2026-01-06 Alexander O Schuth Sell 17,218 17 284,097
2025-08-13 Ho Carole Sell 806 15 11,800
2025-08-13 Carole Ho Sell 806 15 11,800
2025-08-12 Schuth Alexander O. Sell 2,937 14 39,884
2025-08-12 Ho Carole Sell 2,937 14 39,884
2025-08-12 Carole Ho Sell 2,937 14 39,884
2025-08-12 Alexander O Schuth Sell 2,937 14 39,884

Who is buying and selling Denali Therapeutics shares in 2026?

The following insiders have bought shares in Denali Therapeutics: Ho Carole. In total, 30,365 $ was bought across 1 transactions. The following insiders have sold shares: Watts Ryan J., Schuth Alexander O., Ryan J Watts, Alexander O Schuth, Ho Carole and others. In total, 17,430,035 $ was sold across 19 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Denali Therapeutics Short Selling 2026: 10.7% Sold Short

Very high short interest: 10.7% of the free float
Short % of free float
10.7%
Assessment
Very high short interest
Short squeeze risk
High
Data source
SEC
Updated daily
The stock has a very high share of short selling. Between 10-20% of the freely traded shares are sold short, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains.

What does this mean for you as an investor?
A short interest of 10.7% means that 10.7% of the freely traded shares in Denali Therapeutics have been borrowed and sold by investors betting on falling prices. On positive surprises (e.g. a strong earnings report), short sellers can be forced to buy back shares quickly to close their positions, which can cause a short squeeze with sharp price gains in a short time.

The next potential catalyst is the earnings report on 8/6/2026. With a short interest of 10.7%, the report can trigger considerable volatility.

Data is updated daily based on official filings with the SEC.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
10.7%

Denali Therapeutics Earnings – ⚡ Reporting TODAY 8/6/2026

The next earnings date for Denali Therapeutics is not yet available. Check the company's investor calendar for more information.



Technical Analysis of Denali Therapeutics 2026 – Signal: Strong Buy

Overall Technical Signal: Strong Buy

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated August 6, 2026.

Technical analysis of Denali Therapeutics (DNLI.US) – RSI 54, MACD positive (bullish), daily candlestick chart August 2026
Denali Therapeutics technical analysis – candlestick chart with RSI and MACD. Updated Aug 6, 2026.

Trend Analysis of Denali Therapeutics Inc

Denali Therapeutics Inc is in a short-term uptrend. The price of $24.42 is 2.1% above the 20-day average ($23.93). Medium term, the picture is positive: the price is 5.3% above the 50-day average ($23.20). Long term, the stock is 22.4% above the 200-day average ($19.96), which confirms a long-term uptrend.

Golden Cross: The 50-day average (23.20) is above the 200-day average (19.96), which is a classic bullish signal for Denali Therapeutics Inc.

Is Denali Therapeutics Inc overbought or oversold?

Denali Therapeutics Inc has an RSI of 54.3, right in the middle of the neutral zone. There is no clear buying or selling pressure.

MACD Analysis for Denali Therapeutics Inc

Daily MACD: MACD is positive (0.059), which means the short-term trend is bullish (the 12-day EMA is above the 26-day EMA). MACD is below the signal line (0.098) by 0.039, which suggests the positive momentum is fading – the trend could be turning.

Weekly MACD: MACD5 is positive (1.498), which indicates a broader bullish long-term trend. MACD5 is above the signal line (1.269) by 0.229, which confirms rising long-term momentum.

Overall MACD assessment: Both the daily and weekly trend are bullish (MACD positive). However, momentum shows signs of weakening on a daily basis. Watch whether the trend holds.

Risk Profile for Denali Therapeutics Inc

Denali Therapeutics Inc has an annual standard deviation of 57.9%, which classifies the stock as high risk. Sizeable price swings are normal, and the stock requires a higher risk tolerance.

Overall Technical Conclusion for Denali Therapeutics Inc

Trend: Positive. The price trades above SMA50 and SMA200.

MACD trend (zero line): Daily bullish (0.059). Weekly bullish (1.498).

MACD momentum (signal): Daily falling. Weekly rising.

RSI: 54.3 – neutral.

Technical signal: Strong Buy

The price is in an uptrend (above SMA50/SMA200) and MACD is positive on both a daily and weekly basis. Trend and MACD trend confirm each other – the strongest technical buy signal.

Frequently Asked Questions About Denali Therapeutics stock in 2026

Should you buy Denali Therapeutics stock now?
Yes, the technical signal for Denali Therapeutics is currently BUY. Denali Therapeutics trades at $24.46 as of 8/6/2026. The overall technical signal is: Strong Buy. The technical analysis shows the following: MACD is positive (bullish trend) at 0.059 with falling momentum (signal: 0.098); RSI is at 54.3 (neutral zone); the stock is in a short-term uptrend (price above the 20-day average); the analyst price target of $34.31 points to 40.3% upside. The stock is in a broader uptrend (above SMA50/SMA200). This is a technical observation based on current data, not investment advice.
What is the price target for Denali Therapeutics stock?
The average analyst price target for Denali Therapeutics is $34.31. The current price is $24.46, which gives an upside of 40.3%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $30.88 and $37.74.
Is Denali Therapeutics a dividend stock?
No, Denali Therapeutics does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Denali Therapeutics stock?
Denali Therapeutics is rated as a stock with high risk. the annual standard deviation is 57.9%, which classifies the stock as high risk.
Is Denali Therapeutics overvalued?
No, Denali Therapeutics is considered undervalued based on the analyst price target (40.3% upside). Denali Therapeutics has the following valuation ratios: a P/S ratio of 3,643.6, a P/B ratio of 3.9. The analyst price target suggests that the stock is undervalued by 40.3%.
Is Denali Therapeutics overbought?
No, Denali Therapeutics is not overbought. RSI is at 54.3 (neutral zone). The technical indicators show: RSI is at 54.3 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 2.2% above the 20-day average (short-term uptrend). In addition, MACD is positive, but momentum is falling.
When is the next Denali Therapeutics earnings report?
Denali Therapeutics reports earnings TODAY, August 6, 2026! The stock currently trades at $24.46. Watch how the price reacts after the release.
Is Denali Therapeutics shorted?
Yes, Denali Therapeutics is shorted with 10.7% of the free float sold short. This is a very high level of short selling, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains. Data is updated daily based on official filings with the SEC.
Are insiders buying Denali Therapeutics stock?
No, insiders are not buying Denali Therapeutics shares – they are net sellers. Across the last 20 reported transactions, the split is 1 purchases and 19 sales, with a net 17,399,670 $ sold. Active sellers include Watts Ryan J., Schuth Alexander O., Ryan J Watts and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Denali Therapeutics a good stock?
Based on our total score, Denali Therapeutics is rated as a poor stock with a total score of 32 out of 100. The stock scores below average on value, quality and momentum – it sits at the lower end of the market. The score is made up of Value: 10/100, Quality: 6/100, Momentum: 81/100. In addition: analysts see 40.3% upside to the price target; technical signal: Strong Buy. Whether Denali Therapeutics is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Denali Therapeutics stock?
The outlook for Denali Therapeutics based on current data: the average analyst price target is $34.31 (+40.3%); the stock is in an uptrend (above SMA50 and SMA200); the next earnings report is due on 8/6/2026, which can move the price. Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Denali Therapeutics stock rising?
Denali Therapeutics is rising right now. The technical indicators show: the price is 2.2% above the 20-day average; short interest is 10.7% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis, insider section and news overview above.
How high can Denali Therapeutics go?
The average analyst price target for Denali Therapeutics is $34.31, which corresponds to a potential gain of 40.3% from the current price of $24.46. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Denali Therapeutics fall?
We lack enough history to give a specific floor for Denali Therapeutics. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Denali Therapeutics do?
Denali Therapeutics laver medicin mod nervesygdomme og sjældne stofskiftesygdomme. De udvikler behandlinger, der kan trænge ind i hjernen, hvilket er ret svært. Denali fokuserer især på at få deres lægemidler frem til de steder, hvor sygdommen opstår. De har en stor pipeline ... The company belongs to the Sundhed sector, more specifically the Bioteknologi industry, is headquartered in USA, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Denali Therapeutics as an investment.
Did Denali Therapeutics raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Denali Therapeutics. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history and the news overview above.
Is Denali Therapeutics making money or losing money?
We have no current profitability data for Denali Therapeutics. See the latest report in the earnings history above.
Can Denali Therapeutics go bankrupt?
The bankruptcy risk of Denali Therapeutics is rated as elevated. Altman Z2 (a model for assessing financial distress) is -0.72 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. Debt relative to equity is 12% (low). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Denali Therapeutics have a lot of debt?
No, Denali Therapeutics has low debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 12%. For the sundhed sector, anything below 80% counts as low debt. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.