Arrowhead Pharmaceuticals (ARWR.US) Price Target 2026/2027: 80% Upside – Rating and Stock Analysis

60.49
Price history for Arrowhead Pharmaceuticals (ARWR.US) – stock price at $60.49, October 2026
Arrowhead Pharmaceuticals stock price – price development 2026. Updated Oct 30, 2026.
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Arrowhead Pharmaceuticals Price Target 2026: Analysts See 78% Upside

The average price target for Arrowhead Pharmaceuticals is $107.71. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 78.06% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.
⚠️ Don’t buy a stock just because of its price targetA price target is the analysts’ estimate of where the stock will trade in 12 months. That estimate is often wrong. A large study of US stocks from 2000 to 2009 found that only 38% of price targets had been met after 12 months. On average, the targets promised 15 percentage points more return than the stocks delivered. Use the price target together with the financials and the trend, not on its own.Source: Bradshaw, Brown and Huang (2013)

Is Arrowhead Pharmaceuticals overvalued or undervalued?

Arrowhead Pharmaceuticals is currently undervalued with a gap of 78.1% relative to the price target.


The current price is $60.49, which places Arrowhead Pharmaceuticals in the undervalued category. The stock is considered undervalued when the price is below $96.94, and overvalued when the price exceeds $118.48.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Arrowhead Pharmaceuticals, the fair value range lies between $96.94 and $118.48.


See the full price target analysis for Arrowhead Pharmaceuticals →

Analyst Ratings for Arrowhead Pharmaceuticals stock in 2026: Strong Buy

15 analysts cover Arrowhead Pharmaceuticals. There is broad agreement on a positive view — 93.4% recommend buying. The average price target is $107.71, which gives an upside of 78.1% from the current price.

Consensus: Strong Buy (4.60/5)
Strong Buy
10 (66.7%)
Buy
4 (26.7%)
Hold
1 (6.7%)
Strong Sell Sell Hold Buy Strong Buy
4.60 out of 5 based on 15 analysts

About Arrowhead Pharmaceuticals – Biotechnology

Arrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. Its pipeline includes Plozasiran to reduce production of apolipoprotein C-III in Phase 3 studies; Zodasiran to reduce production of angiopoietin-like protein 3 in Phase 3 clinical trials; ARO-DIMER-PA, a dual functional RNAi molecule in a Phase 1/2a clinical trials; and ARO-PNPLA3, an investigational RNAi therapeutic in Phase 1 clinical trials. The company also develops ARO-INHBE, to reduce the hepatic expression of the INHBE gene and its secreted gene product, Activin E in Phase 1/2a clinical trials; ARO-ALK7 to silence adipocyte expression of the ACVR1C gene in Phase 1/2a clinical trials; ARO-RAGE to reduce production of the receptor for advanced glycation end products in Phase 1/2a clinical trials; and ARO-MAPT, an investigational RNAi-based therapy. In addition, it is developing ARO-C3 to reduce production of C3 in Phase 1/2a clinical trials; and ARO-CFB to reduce hepatic expression of CFB in a Phase 1/2a clinical trials. The company has collaboration and license Agreements with Glaxosmithkline Intellectual Property (No. 3) Limited; Takeda Pharmaceutical Company Limited; Amgen Inc.; and Sarepta Therapeutics, Inc. Arrowhead Pharmaceuticals, Inc. was founded in 2003 and is headquartered in Pasadena, California. Read more about the company

Key Figures for Arrowhead Pharmaceuticals

$8.5B Market cap
$669M Revenue
Biotechnology Industry
- P/E
12.70 P/S
17.91 P/B
United States Listed on exchange

What kind of stock is Arrowhead Pharmaceuticals?

Speculative stock

Arrowhead Pharmaceuticals is classified as a speculative stock.

Score Overview for Arrowhead Pharmaceuticals

💰 Value Score 5/100 (Very Low)
⭐ Quality Score 7/100 (Very Low)
🚀 Momentum Score 26/100 (Low)
📊 Total Score 12/100

⚠️ 4 red flags identified 3 critical

Our analysis has identified 4 potential risk factors in Arrowhead Pharmaceuticals that investors should be aware of.

🚨 High debt: The debt-to-equity ratio is 512% – the company carries considerably more debt than equity, which raises the financial risk.
🚨 Negative profit margin: The profit margin is -47.8% – the company is losing money on its operations.
🚨 Negative return on equity: ROE is -55.2% – the company is generating a negative return for shareholders.
⚠️ High short interest: 10.8% of the shares are sold short – many professional investors are betting on price declines.

📈 Valuation

The P/S ratio is 12.7 (high — the market pays a premium for the revenue). The P/B ratio is 17.9.

💵 Profitability & Growth

The latest quarterly earnings grew 9.8% year over year.

🏦 Financial Health

The Piotroski score is 4 out of 9 — average financial health. Altman Z2 is 1.13 (middle zone — moderate). The debt-to-equity ratio (D/E) is 511.6% — high debt, which raises the risk.

🚀 Momentum & Short Interest

Short interest is 10.79% — very high, the market is skeptical.

Insider Trading in Arrowhead Pharmaceuticals 2026: Only sells

In 2026, insiders at Arrowhead Pharmaceuticals have made 20 transactions, all of which were sales. On a net basis, insiders took $20,280,490 out of the stock. Active insiders include PERRY MICHAEL S, OLUKOTUN ADEOYE Y, Lu Hongbo and others. Over the last 3 months: only sells.

Last 3 Months: Only sells

Insiders have exclusively sold shares over the last 3 months.

Over the last 3 months: 0 purchases and 2 sales. A net $1,186,600 out of the stock.

All Transactions: Only sells

Insiders have exclusively sold shares in the recent period. This can suggest management sees limited opportunity.

Across the last 20 transactions: 0 purchases and 20 sales. A net $20,280,490 out of the stock.

Latest sale: PERRY MICHAEL S sold 11,600 shares at $87.30 each on 2026-08-18.

Who is selling: PERRY MICHAEL S, OLUKOTUN ADEOYE Y, Lu Hongbo, Hamilton James C, Apel Daniel Joseph and others.

Latest Insider Trades in Arrowhead Pharmaceuticals (2026)

The table shows the last 20 reported insider transactions in Arrowhead Pharmaceuticals. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-08-18 PERRY MICHAEL S Sell 11,600 87 1,012,680
2026-08-18 OLUKOTUN ADEOYE Y Sell 2,000 87 173,920
2026-05-12 Lu Hongbo Sell 2,970 77 228,334
2026-04-23 Hamilton James C Sell 10,000 75 750,000
2026-04-22 Apel Daniel Joseph Sell 3,208 72 230,719
2026-03-05 Hamilton James C Sell 10,000 64 641,900
2026-01-05 O'Brien Patrick Sell 4,368 68 297,024
2026-01-05 Hamilton James C Sell 4,625 68 314,500
2026-01-02 Anzalone Christopher Richard Sell 7,416 66 492,348
2025-12-29 Anzalone Christopher Richard Sell 35,181 69 2,416,583

Who is buying and selling Arrowhead Pharmaceuticals shares in 2026?

The following insiders have sold shares: PERRY MICHAEL S, OLUKOTUN ADEOYE Y, Lu Hongbo, Hamilton James C, Apel Daniel Joseph and others. In total, $20,280,490 was sold across 20 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Arrowhead Pharmaceuticals Short Selling 2026: 10.8% Sold Short

Very high short interest: 10.8% of the free float
Short % of free float
10.8%
Assessment
Very high short interest
Short squeeze risk
High
Data source
EODHD
Reported about twice a month
The stock has a very high share of short selling. Between 10-20% of the freely traded shares are sold short, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains.

What does this mean for you as an investor?
A short interest of 10.8% means that 10.8% of the freely traded shares in Arrowhead Pharmaceuticals have been borrowed and sold by investors betting on falling prices. On positive surprises (e.g. a strong earnings report), short sellers can be forced to buy back shares quickly to close their positions, which can cause a short squeeze with sharp price gains in a short time.

The next potential catalyst is the earnings report on Nov 24, 2026. With a short interest of 10.8%, the report can trigger considerable volatility.

Short interest comes from our data provider EODHD. The figure is reported about twice a month; we check it every trading day.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
▲
10.8%

When Does Arrowhead Pharmaceuticals Report Earnings – Next Date: Nov 24, 2026

The next earnings report from Arrowhead Pharmaceuticals is scheduled for November 24, 2026, after the market closes. This report covers the third quarter (Q3), which ended on September 30, 2026.



Technical Analysis of Arrowhead Pharmaceuticals 2026 – Signal: Strong Sell

Overall Technical Signal: Strong Sell

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated October 30, 2026.

Technical analysis of Arrowhead Pharmaceuticals (ARWR.US) – RSI 43, MACD negative (bearish), daily candlestick chart October 2026
Arrowhead Pharmaceuticals technical analysis – candlestick chart with RSI, MACD and volume profile. Updated Oct 30, 2026.

Trend Analysis of Arrowhead Pharmaceuticals, Inc

Arrowhead Pharmaceuticals, Inc is in a short-term uptrend. The price of $60.49 is 1.3% above the 20-day average ($59.74). Medium term, the picture is negative: the price is 14.0% below the 50-day average ($70.34). Long term, the stock is 15.7% below the 200-day average ($71.76), which signals a long-term downtrend.

Death Cross: The 50-day average (70.34) is below the 200-day average (71.76), which is a classic bearish signal for Arrowhead Pharmaceuticals, Inc.

Is Arrowhead Pharmaceuticals, Inc overbought or oversold?

Arrowhead Pharmaceuticals, Inc has an RSI of 42.6. The stock sits in the lower part of the neutral zone, which points to weak momentum without being oversold. In the current downtrend, be careful about reading this as a buying opportunity.

MACD Analysis for Arrowhead Pharmaceuticals, Inc

Daily MACD: MACD is negative (-2.796), which means the short-term trend is bearish (the 12-day EMA is below the 26-day EMA). MACD is above the signal line (-3.706) by 0.910, which suggests the negative momentum is fading – a potential trend reversal could be ahead.

Weekly MACD: MACD5 is negative (-2.159), which indicates a broader bearish long-term trend. MACD5 is below the signal line (1.987) by 4.146, which confirms continued negative long-term momentum.

Overall MACD assessment: Both the daily and weekly trend are bearish (MACD negative). However, momentum shows signs of improving on a daily basis – a potential trend reversal could be ahead, but it is not confirmed yet.

Overall Technical Conclusion for Arrowhead Pharmaceuticals, Inc

Trend: Negative. The price trades below SMA50 and SMA200.

MACD trend (zero line): Daily bearish (-2.796). Weekly bearish (-2.159).

MACD momentum (signal): Daily rising. Weekly falling.

RSI: 42.6 – neutral.

Technical signal: Strong Sell

The price is in a downtrend (below SMA50/SMA200) and MACD is negative on both a daily and weekly basis. Avoid buying and consider closing existing positions.

Frequently Asked Questions About Arrowhead Pharmaceuticals stock in 2026

Should you buy Arrowhead Pharmaceuticals stock now?
No, the technical signal for Arrowhead Pharmaceuticals is currently Strong Sell. Arrowhead Pharmaceuticals trades at $60.49 as of Oct 30, 2026. The technical analysis shows the following: MACD is negative (bearish trend) at -2.796 with rising momentum (signal: -3.706); RSI is at 42.6 (neutral zone); the stock is in a short-term uptrend (price above the 20-day average); the analyst price target of $107.71 points to 78.1% upside. The stock is in a broader downtrend (below SMA50/SMA200). Buying in a downtrend is generally not recommended. This is a technical observation based on current data, not investment advice.
What is the price target for Arrowhead Pharmaceuticals stock?
The average analyst price target for Arrowhead Pharmaceuticals is $107.71. The current price is $60.49, which gives an upside of 78.1%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $96.94 and $118.48.
Is Arrowhead Pharmaceuticals a dividend stock?
No, Arrowhead Pharmaceuticals does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Arrowhead Pharmaceuticals stock?
Arrowhead Pharmaceuticals is rated as a stock in the risk category Unknown. Detailed risk data is currently not available.
Is Arrowhead Pharmaceuticals overvalued?
No, Arrowhead Pharmaceuticals is considered undervalued based on the analyst price target (78.1% upside). Arrowhead Pharmaceuticals has the following valuation ratios: a P/S ratio of 12.7, a P/B ratio of 17.9. The analyst price target suggests that the stock is undervalued by 78.1%.
Is Arrowhead Pharmaceuticals overbought?
No, Arrowhead Pharmaceuticals is not overbought. RSI is at 42.6 (neutral zone). The technical indicators show: RSI is at 42.6 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 1.3% above the 20-day average (short-term uptrend). In addition, MACD is negative, but momentum is rising (possible trend reversal).
When is the next Arrowhead Pharmaceuticals earnings report?
Arrowhead Pharmaceuticals reports its next earnings on November 24, 2026. The stock currently trades at $60.49.
Is Arrowhead Pharmaceuticals shorted?
Yes, Arrowhead Pharmaceuticals is shorted with 10.8% of the free float sold short. This is a very high level of short selling, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains. The figure comes from our data provider EODHD, is reported about twice a month, and we check it every trading day.
Are insiders buying Arrowhead Pharmaceuticals stock?
No, insiders are not buying Arrowhead Pharmaceuticals shares – they are net sellers. Over the last 3 months, insiders have made 0 purchases and 2 sales. On a net basis, 1,186,600 $ worth of shares were sold. Across the last 20 reported transactions, the split is 0 purchases and 20 sales, with a net 20,280,490 $ sold. Active sellers include PERRY MICHAEL S, OLUKOTUN ADEOYE Y, Lu Hongbo and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Arrowhead Pharmaceuticals a good stock?
Based on our total score, Arrowhead Pharmaceuticals is rated as a disastrous stock with a total score of 12 out of 100. The stock scores very low on value, quality and momentum – it is among the worst in our database. The score is made up of Value: 5/100, Quality: 7/100, Momentum: 26/100. In addition: analysts see 78.1% upside to the price target. Whether now is the time to buy is a separate question: the technical signal is Strong Sell. Whether Arrowhead Pharmaceuticals is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Arrowhead Pharmaceuticals stock?
The outlook for Arrowhead Pharmaceuticals based on current data: the average analyst price target is $107.71 (+78.1%); the stock is in a downtrend (below SMA50 and SMA200); the next earnings report is due on Nov 24, 2026, which can move the price. Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Arrowhead Pharmaceuticals stock moving?
Arrowhead Pharmaceuticals is stable right now. The technical indicators show: the price is close to the 20-day average; short interest is 10.8% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis and insider section above.
How high can Arrowhead Pharmaceuticals go?
The average analyst price target for Arrowhead Pharmaceuticals is $107.71, which corresponds to a potential gain of 78.1% from the current price of $60.49. The stock has traded between $37.06 and $95.49 over the last 52 weeks. The price is 36.7% below the 52-week high, which can indicate potential if the underlying fundamentals are intact. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Arrowhead Pharmaceuticals fall?
The stock has traded as low as $37.06 over the last 52 weeks — that is 38.7% below the current price of $60.49. The biggest decline (drawdown) in the same period was 61.2% from high to low. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Arrowhead Pharmaceuticals do?
Arrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. Its pipeline includes Plozasiran to reduce production of apolipoprotein C-III in Phase 3 studies; Zodasiran to reduce production of angiopoietin-like protein 3 in... The company belongs to the Healthcare sector, more specifically the Biotechnology industry, is headquartered in United States, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Arrowhead Pharmaceuticals as an investment.
Did Arrowhead Pharmaceuticals raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Arrowhead Pharmaceuticals. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history above.
Is Arrowhead Pharmaceuticals making money or losing money?
No, Arrowhead Pharmaceuticals is currently not making money — the company is losing money with a negative profit margin of -47.8%, a substantial loss. That means the business loses money on every dollar of revenue. The operating margin (profit before interest and taxes) is also negative at -226.0% — so it is not just financing costs weighing on the result. For growth stocks investing in expansion this is normal — but it raises the risk if the company does not reach break-even before its capital runs out.
Can Arrowhead Pharmaceuticals go bankrupt?
The bankruptcy risk of Arrowhead Pharmaceuticals is rated as moderate. Altman Z2 (a model for assessing financial distress) is 1.13 — that places the company in the middle zone. The Piotroski score (financial health 0-9, higher is better) is 4 — which is average. Debt relative to equity is 512% (high). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Arrowhead Pharmaceuticals have a lot of debt?
Yes, Arrowhead Pharmaceuticals has elevated debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 512%. For the healthcare sector, anything above 150% counts as elevated — that raises the financial risk, especially if interest rates rise or earnings fall. In healthcare, 80-150% is typical — large pharma companies carry debt for research and acquisitions. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.

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