Krystal Biotech (KRYS.US) Price Target 2026/2027: 20% Upside – Rating and Stock Analysis

324,24
-0,47%
Price history for Krystal Biotech (KRYS.US) – stock price at 324.24 $, August 2026
Krystal Biotech stock price – price development 2026. Updated Aug 6, 2026.
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Krystal Biotech Price Target 2026: Analysts See 18% Upside

The average price target for Krystal Biotech is $382.86. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 18,08% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is Krystal Biotech overvalued or undervalued?

Krystal Biotech is currently undervalued with a gap of 18.1% relative to the price target.


The current price is $324.24, which places Krystal Biotech in the undervalued category. The stock is considered undervalued when the price is below $344.57, and overvalued when the price exceeds $421.15.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Krystal Biotech, the fair value range lies between $344.57 and $421.15.


See the full price target analysis for Krystal Biotech →

Analyst Ratings for Krystal Biotech stock in 2026: Strong Buy

11 analysts cover Krystal Biotech. There is broad agreement on a positive view — 90.9% recommend buying. The average price target is $382.86, which gives an upside of 18.1% from the current price.

Consensus: Strong Buy (4.64/5)
Strong Buy
8 (72.7%)
Buy
2 (18.2%)
Hold
1 (9.1%)
Strong Sell Sell Hold Buy Strong Buy
4.64 out of 5 based on 11 analysts

About Krystal Biotech – Bioteknologi

Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, manufactures, and commercializes genetic medicines to treat diseases with high unmet medical needs in the United States. The company commercializes VYJUVEK (beremagene geperpavec-svdt, or B-VEC) for the treatment of dystrophic epidermolysis bullosa (DEB). It also develops KB803 for ocular complications of dystrophic epidermolysis bullosa; KB801 for neurotrophic keratitis; KB407, which is in Phase 1 clinical trials for treating cystic fibrosis; KB111 for Hailey-Hailey disease; KB707 for solid tumors; KB304 for dynamic wrinkles; KB707 that is in Phase 1/2 clinical trials for the treatment of anti-PD-1 relapsed/refractory; KB408, which is in Phase 1 clinical trials for treating Alpha-1 antitrypsin deficiency; and KB301 that is in Phase 2 clinical trials for treating aesthetic skin conditions, as well as in open label study with ophthalmic B-VEC for treating for ocular complications of deb. Krystal Biotech, Inc. was founded in 2016 and is headquartered in Pittsburgh, Pennsylvania. Read more about the company

Key Figures for Krystal Biotech

$ 9,6B Market cap
$ 440M Revenue
Bioteknologi Industry
41.85 P/E
21.82 P/S
7.88 P/B
USA Listed on exchange
Sundhed Sector

What kind of stock is Krystal Biotech?

Growth stock Momentum stock

Krystal Biotech is classified as a growth stock and momentum stock. This means the stock combines several attractive traits, and strong price momentum.

Score Overview for Krystal Biotech

💰 Value Score 19/100 (Very Low)
⭐ Quality Score 90/100 (Very High)
🚀 Momentum Score 73/100 (High)
📊 Total Score 60/100

⚠️ 1 red flag identified

Our analysis has identified 1 potential risk factor in Krystal Biotech that investors should be aware of.

⚠️ High short interest: 19.5% of the shares are sold short – many professional investors are betting on price declines.

📈 Valuation

Krystal Biotech trades at a P/E ratio of 41.9, which is above the market average. The forward P/E is 45.0. The P/S ratio is 21.8 (high — the market pays a premium for the revenue). The P/B ratio is 7.9.

💵 Profitability & Growth

Krystal Biotech has a profit margin of 54.8% (excellent) and an operating margin of 49.0%. Return on equity (ROE) is 20.1% — excellent return on equity. Return on assets (ROA) is 9.4%. The latest quarterly earnings grew 38.8% year over year — strong growth.

🏦 Financial Health

The Piotroski score is 5 out of 9 — average financial health. Altman Z2 is 15.32 (healthy balance sheet — low risk). The debt-to-equity ratio (D/E) is 11.6% — low debt, a solid balance sheet.

🚀 Momentum & Short Interest

Short interest is 19.47% — very high, the market is skeptical.

Insider Trading in Krystal Biotech 2026: The Signal Is negative

In 2026, insiders at Krystal Biotech have made 20 transactions, all of which were sales. On a net basis, insiders took 32,595,959 $ out of the stock. Active insiders include Thomas John Charles, Krishnan Suma, Krishnan Krish S and others. In the short term (last 3 months), the insider signal is negative.

Short-Term Signal (3 months): Negative

Insiders have exclusively sold shares over the last 3 months.

Over the last 3 months: 0 purchases and 4 sales. A net 740,815 $ out of the stock.

Long-Term Signal (all transactions): Negative

Insiders have exclusively sold shares in the recent period. This can suggest management sees limited opportunity.

Across the last 20 transactions: 0 purchases and 20 sales. A net 32,595,959 $ out of the stock.

Latest sale: Thomas John Charles sold 1,000 shares at 347 $ each on 2026-06-25.

Who is selling: Thomas John Charles, Krishnan Suma, Krishnan Krish S, ROMANO KATHRYN, JANNEY DANIEL and others.

Latest Insider Trades in Krystal Biotech (2026)

The table shows the last 20 reported insider transactions in Krystal Biotech. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-06-25 Thomas John Charles Sell 1,000 347 347,270
2026-06-04 Krishnan Suma Sell 320 312 99,728
2026-06-04 Krishnan Krish S Sell 320 312 99,914
2026-05-26 Thomas John Charles Sell 642 302 193,903
2026-03-04 Krishnan Suma Sell 407 266 108,433
2026-03-04 Krishnan Krish S Sell 483 267 128,748
2026-03-02 ROMANO KATHRYN Sell 750 268 200,700
2026-02-27 ROMANO KATHRYN Sell 7,500 276 2,067,300
2026-02-27 Krishnan Suma Sell 22,500 276 6,201,900
2026-02-27 Krishnan Krish S Sell 8,750 276 2,411,850

Who is buying and selling Krystal Biotech shares in 2026?

The following insiders have sold shares: Thomas John Charles, Krishnan Suma, Krishnan Krish S, ROMANO KATHRYN, JANNEY DANIEL and others. In total, 32,595,959 $ was sold across 20 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Krystal Biotech Short Selling 2026: 19.5% Sold Short

Very high short interest: 19.5% of the free float
Short % of free float
19.5%
Assessment
Very high short interest
Short squeeze risk
High
Data source
SEC
Updated daily
The stock has a very high share of short selling. Between 10-20% of the freely traded shares are sold short, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains.

What does this mean for you as an investor?
A short interest of 19.5% means that 19.5% of the freely traded shares in Krystal Biotech have been borrowed and sold by investors betting on falling prices. On positive surprises (e.g. a strong earnings report), short sellers can be forced to buy back shares quickly to close their positions, which can cause a short squeeze with sharp price gains in a short time.

Data is updated daily based on official filings with the SEC.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
19.5%

When Does Krystal Biotech Report Earnings?

The next earnings date for Krystal Biotech is not yet available. Check the company's investor calendar for more information.



Technical Analysis of Krystal Biotech 2026 – Signal: Hold

Overall Technical Signal: Hold

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated August 6, 2026.

Technical analysis of Krystal Biotech (KRYS.US) – RSI 43, MACD negative (bearish), daily candlestick chart August 2026
Krystal Biotech technical analysis – candlestick chart with RSI and MACD. Updated Aug 6, 2026.

Trend Analysis of Krystal Biotech, Inc

Krystal Biotech, Inc is in a short-term downtrend. The price of $325.78 is 5.8% below the 20-day average ($345.75). Medium term, the picture is negative: the price is 3.8% below the 50-day average ($338.51). Long term, the stock is 18.9% above the 200-day average ($273.93), which confirms a long-term uptrend.

Golden Cross: The 50-day average (338.51) is above the 200-day average (273.93), which is a classic bullish signal for Krystal Biotech, Inc.

Is Krystal Biotech, Inc overbought or oversold?

Krystal Biotech, Inc has an RSI of 43.3. The stock sits in the lower part of the neutral zone, which points to weak momentum without being oversold.

MACD Analysis for Krystal Biotech, Inc

Daily MACD: MACD is negative (-3.300), which means the short-term trend is bearish (the 12-day EMA is below the 26-day EMA). MACD is below the signal line (0.699) by 3.999, which confirms growing negative momentum in the downtrend.

Weekly MACD: MACD5 is positive (28.749), which indicates a broader bullish long-term trend. MACD5 is above the signal line (28.023) by 0.726, which confirms rising long-term momentum.

Overall MACD assessment: The daily and weekly MACD give conflicting signals. The long-term trend is bullish, but the short-term trend is bearish. Short-term momentum is still falling – a deeper pullback is possible.

Risk Profile for Krystal Biotech, Inc

Krystal Biotech, Inc has an annual standard deviation of 39.3%, which classifies the stock as medium risk. The price can swing noticeably when the market moves.

Overall Technical Conclusion for Krystal Biotech, Inc

Trend: Neutral/mixed.

MACD trend (zero line): Daily bearish (-3.300). Weekly bullish (28.749).

MACD momentum (signal): Daily falling. Weekly rising.

RSI: 43.3 – neutral.

Technical signal: Hold

The signals are mixed – trend and MACD point in different directions. Wait until MACD crosses the zero line in the direction of the trend before acting.

Frequently Asked Questions About Krystal Biotech stock in 2026

Should you buy Krystal Biotech stock now?
The technical signal for Krystal Biotech is currently NEUTRAL. Krystal Biotech trades at $324.24 as of 8/6/2026. The overall technical signal is: Hold. The technical analysis shows the following: MACD is negative (bearish trend) at -3.300 with falling momentum (signal: 0.699); RSI is at 43.3 (neutral zone); the stock is in a short-term downtrend (price below the 20-day average); the analyst price target of $382.86 points to 18.1% upside. This is a technical observation based on current data, not investment advice.
What is the price target for Krystal Biotech stock?
The average analyst price target for Krystal Biotech is $382.86. The current price is $324.24, which gives an upside of 18.1%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $344.57 and $421.15.
Is Krystal Biotech a dividend stock?
No, Krystal Biotech does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Krystal Biotech stock?
Krystal Biotech is rated as a stock with moderate risk. the annual standard deviation is 39.3%, which classifies the stock as moderate risk.
Is Krystal Biotech overvalued?
No, Krystal Biotech is considered undervalued based on the analyst price target (18.1% upside). Krystal Biotech has the following valuation ratios: a P/E ratio of 41.9 (highly valued), a P/S ratio of 21.8, a P/B ratio of 7.9. The analyst price target suggests that the stock is undervalued by 18.1%.
Is Krystal Biotech overbought?
No, Krystal Biotech is not overbought. RSI is at 43.3 (neutral zone). The technical indicators show: RSI is at 43.3 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 6.2% below the 20-day average (short-term downtrend). In addition, MACD is negative with falling momentum (bearish).
When is the next Krystal Biotech earnings report?
The date of the next earnings report for Krystal Biotech has not been published yet. Check the company's investor calendar for updates.
Is Krystal Biotech shorted?
Yes, Krystal Biotech is shorted with 19.5% of the free float sold short. This is a very high level of short selling, which points to considerable bearish sentiment. A positive earnings report or unexpectedly good news can trigger a short squeeze with sharp price gains. Data is updated daily based on official filings with the SEC.
Are insiders buying Krystal Biotech stock?
No, insiders are not buying Krystal Biotech shares – they are net sellers. Over the last 3 months, insiders have made 0 purchases and 4 sales. On a net basis, 740,815 $ worth of shares were sold. Across the last 20 reported transactions, the split is 0 purchases and 20 sales, with a net 32,595,959 $ sold. Active sellers include Thomas John Charles, Krishnan Suma, Krishnan Krish S and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Krystal Biotech a good stock?
Based on our total score, Krystal Biotech is rated as a good stock with a total score of 61 out of 100. The stock scores above average on value, quality and momentum – it is among the top 39% in our database. The score is made up of Value: 19/100, Quality: 90/100, Momentum: 73/100. In addition: analysts see 18.1% upside to the price target; technical signal: Hold. Whether Krystal Biotech is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Krystal Biotech stock?
The outlook for Krystal Biotech based on current data: the average analyst price target is $382.86 (+18.1%); the P/E ratio is 41.9 (high – the market expects growth). Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Krystal Biotech stock falling?
Krystal Biotech is falling right now. The technical indicators show: the price is 6.2% below the 20-day average; MACD is negative with falling momentum (bearish signal); short interest is 19.5% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis, insider section and news overview above.
How high can Krystal Biotech go?
The average analyst price target for Krystal Biotech is $382.86, which corresponds to a potential gain of 18.1% from the current price of $324.24. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Krystal Biotech fall?
We lack enough history to give a specific floor for Krystal Biotech. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Krystal Biotech do?
Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, manufactures, and commercializes genetic medicines to treat diseases with high unmet medical needs in the United States. The company commercializes VYJUVEK (beremagene geperpavec-svdt, or B-V... The company belongs to the Sundhed sector, more specifically the Bioteknologi industry, is headquartered in USA, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Krystal Biotech as an investment.
Did Krystal Biotech raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Krystal Biotech. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history and the news overview above.
Is Krystal Biotech making money or losing money?
Yes, Krystal Biotech is making money, not losing it. The company has a profit margin (the share of revenue left over as profit) of 54.8% — which is excellent. The operating margin (profit before interest and taxes) is 49.0%. At a P/E ratio of 41.9, you currently pay 41.9 dollars for every dollar of the company's annual earnings. A consistently profitable company is usually more resilient than growth stocks that are not yet making money.
Can Krystal Biotech go bankrupt?
The bankruptcy risk of Krystal Biotech is rated as low. Altman Z2 (a model for assessing financial distress) is 15.32 — that places the company in the healthy zone. The company has a healthy balance sheet with limited debt relative to earnings and assets. The Piotroski score (financial health 0-9, higher is better) is 5 — which is average. Debt relative to equity is 12% (low). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Krystal Biotech have a lot of debt?
No, Krystal Biotech has low debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 12%. For the sundhed sector, anything below 80% counts as low debt. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.