Axsome Therapeutics (AXSM.US) Price Target 2026/2027: 35% Upside – Rating and Stock Analysis

213,06
0,10%
Price history for Axsome Therapeutics (AXSM.US) – stock price at 213.06 $, August 2026
Axsome Therapeutics stock price – price development 2026. Updated Aug 6, 2026.
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Axsome Therapeutics Price Target 2026: Analysts See 33% Upside

The average price target for Axsome Therapeutics is $282.32. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 32,51% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is Axsome Therapeutics overvalued or undervalued?

Axsome Therapeutics is currently undervalued with a gap of 32.5% relative to the price target.


The current price is $213.06, which places Axsome Therapeutics in the undervalued category. The stock is considered undervalued when the price is below $254.09, and overvalued when the price exceeds $310.55.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Axsome Therapeutics, the fair value range lies between $254.09 and $310.55.


See the full price target analysis for Axsome Therapeutics →

Analyst Ratings for Axsome Therapeutics stock in 2026: Strong Buy

19 analysts cover Axsome Therapeutics. There is broad agreement on a positive view — 100% recommend buying. The average price target is $282.32, which gives an upside of 32.5% from the current price.

Consensus: Strong Buy (4.74/5)
Strong Buy
14 (73.7%)
Buy
5 (26.3%)
Strong Sell Sell Hold Buy Strong Buy
4.74 out of 5 based on 19 analysts

About Axsome Therapeutics – Bioteknologi

Axsome Therapeutics (AXSM) driver en biopharma-virksomhed, der udvikler og sælger nye behandlinger for lidelser i centralnervesystemet (CNS) i USA. De tjener penge på flere produkter, som allerede er på markedet. Blandt deres vigtigste produkter er Auvelity, som bruges mod svær depression, og Sunosi, der hjælper patienter med narkolepsi eller søvnapnø mod ekstrem træthed om dagen. Axsome har også Symbravo, som er en hurtigvirkende behandling mod migræne. Virksomheden arbejder samtidig med at få flere lægemidler godkendt, for eksempel AXS-05, der også skal behandle depression. Deres fokus er klart på det amerikanske marked, hvor de driver hele forretningen. AXSM blev etableret i 2012. Read more about the company

Key Figures for Axsome Therapeutics

$ 10,9B Market cap
$ 708M Revenue
Bioteknologi Industry
- P/E
15.42 P/S
205.50 P/B
USA Listed on exchange
axsome.com Website
Sundhed Sector

What kind of stock is Axsome Therapeutics?

Speculative stock

Axsome Therapeutics is classified as a speculative stock.

Score Overview for Axsome Therapeutics

💰 Value Score 4/100 (Very Low)
⭐ Quality Score 14/100 (Very Low)
🚀 Momentum Score 59/100 (Neutral)
📊 Total Score 25/100

⚠️ 4 red flags identified 4 critical

Our analysis has identified 4 potential risk factors in Axsome Therapeutics that investors should be aware of.

🚨 High debt: The debt-to-equity ratio is 897% – the company carries considerably more debt than equity, which raises the financial risk.
🚨 Weak balance sheet (elevated risk): Altman Z2 is -6.30 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative profit margin: The profit margin is -26.6% – the company is losing money on its operations.
🚨 Negative return on equity: ROE is -349.4% – the company is generating a negative return for shareholders.

📈 Valuation

The P/S ratio is 15.4 (high — the market pays a premium for the revenue). The P/B ratio is 205.5.

🏦 Financial Health

The Piotroski score is 4 out of 9 — average financial health. Altman Z2 is -6.30 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 897.1% — high debt, which raises the risk.

🚀 Momentum & Short Interest

Short interest is 9.20% — elevated, some investors are betting on a decline.

Insider Trading in Axsome Therapeutics 2026: The Signal Is negative

In 2026, insiders at Axsome Therapeutics have made 20 transactions – split into 1 purchases and 19 sales. On a net basis, insiders took 59,590,058 $ out of the stock. Active insiders include Coleman Mark, TABUTEAU HERRIOT, JEFFS ROGER and others. In the short term (last 3 months), the insider signal is negative.

Short-Term Signal (3 months): Negative

Insiders have exclusively sold shares over the last 3 months.

Over the last 3 months: 0 purchases and 11 sales. A net 36,292,443 $ out of the stock.

Long-Term Signal (all transactions): Mostly negative

Insiders have sold considerably more than they have bought. At large companies this can be due to planned sales (10b5-1 plans) and is not necessarily a negative signal.

Across the last 20 transactions: 1 purchases and 19 sales. A net 59,590,058 $ out of the stock.

Latest purchase: Coleman Mark bought 6,250 shares at 5 $ each on 2026-02-23. The stock has since risen 4200%.

Latest sale: TABUTEAU HERRIOT sold 49,666 shares at 240 $ each on 2026-07-01.

Who is buying: Coleman Mark.

Who is selling: TABUTEAU HERRIOT, JEFFS ROGER, Mahony Susan, Coleman Mark, Pizzie Nick and others.

Latest Insider Trades in Axsome Therapeutics (2026)

The table shows the last 20 reported insider transactions in Axsome Therapeutics. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-07-01 TABUTEAU HERRIOT Sell 49,666 240 11,932,257
2026-06-11 JEFFS ROGER Sell 286 249 71,248
2026-06-10 Mahony Susan Sell 300 246 73,854
2026-06-10 JEFFS ROGER Sell 286 246 70,407
2026-06-10 Coleman Mark Sell 643 249 160,107
2026-06-09 TABUTEAU HERRIOT Sell 49,670 241 11,970,967
2026-06-09 Pizzie Nick Sell 33,000 240 7,922,970
2026-06-09 Mahony Susan Sell 300 237 71,163
2026-06-02 Coleman Mark Sell 5,537 223 1,236,910
2026-06-01 Coleman Mark Sell 6,000 230 1,381,800

Who is buying and selling Axsome Therapeutics shares in 2026?

The following insiders have bought shares in Axsome Therapeutics: Coleman Mark. In total, 30,938 $ was bought across 1 transactions. The following insiders have sold shares: TABUTEAU HERRIOT, JEFFS ROGER, Mahony Susan, Coleman Mark, Pizzie Nick and others. In total, 59,620,996 $ was sold across 19 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Axsome Therapeutics Short Selling 2026: 9.2% Sold Short

High short interest: 9.2% of the free float
Short % of free float
9.2%
Assessment
High short interest
Short squeeze risk
Moderate
Data source
SEC
Updated daily
The stock has a high share of short selling. Between 5-10% of the freely traded shares are sold short, which suggests some investors are betting on falling prices. Positive surprises can lead to a moderate short squeeze.

What does this mean for you as an investor?
A short interest of 9.2% means that 9.2% of the freely traded shares in Axsome Therapeutics have been borrowed and sold by investors betting on falling prices.

The next potential catalyst is the earnings report on 8/10/2026. With a short interest of 9.2%, the report can trigger considerable volatility.

Data is updated daily based on official filings with the SEC.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
9.2%

When Does Axsome Therapeutics Report Earnings – Next Date: 8/10/2026

The next earnings report from Axsome Therapeutics is scheduled for August 10, 2026, before the market opens. This report covers the second quarter (Q2), which ended on June 30, 2026.



Technical Analysis of Axsome Therapeutics 2026 – Signal: Hold

Overall Technical Signal: Hold

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated August 6, 2026.

Technical analysis of Axsome Therapeutics (AXSM.US) – RSI 37, MACD negative (bearish), daily candlestick chart August 2026
Axsome Therapeutics technical analysis – candlestick chart with RSI and MACD. Updated Aug 6, 2026.

Trend Analysis of Axsome Therapeutics, Inc

Axsome Therapeutics, Inc is in a short-term downtrend. The price of $212.85 is 7.9% below the 20-day average ($231.01). Medium term, the picture is negative: the price is 10.3% below the 50-day average ($237.31). Long term, the stock is 14.1% above the 200-day average ($186.50), which confirms a long-term uptrend.

Golden Cross: The 50-day average (237.31) is above the 200-day average (186.50), which is a classic bullish signal for Axsome Therapeutics, Inc.

Is Axsome Therapeutics, Inc overbought or oversold?

Axsome Therapeutics, Inc has an RSI of 36.5. The stock sits in the lower part of the neutral zone, which points to weak momentum without being oversold.

MACD Analysis for Axsome Therapeutics, Inc

Daily MACD: MACD is negative (-5.874), which means the short-term trend is bearish (the 12-day EMA is below the 26-day EMA). MACD is below the signal line (-3.001) by 2.873, which confirms growing negative momentum in the downtrend.

Weekly MACD: MACD5 is positive (18.886), which indicates a broader bullish long-term trend. MACD5 is below the signal line (21.510) by 2.624, which suggests the long-term momentum is fading – the positive trend could come under pressure.

Overall MACD assessment: The daily and weekly MACD give conflicting signals. The long-term trend is bullish, but the short-term trend is bearish. Short-term momentum is still falling – a deeper pullback is possible.

Risk Profile for Axsome Therapeutics, Inc

Axsome Therapeutics, Inc has an annual standard deviation of 42.9%, which classifies the stock as medium risk. The price can swing noticeably when the market moves.

Overall Technical Conclusion for Axsome Therapeutics, Inc

Trend: Neutral/mixed.

MACD trend (zero line): Daily bearish (-5.874). Weekly bullish (18.886).

MACD momentum (signal): Daily falling. Weekly falling.

RSI: 36.5 – neutral.

Technical signal: Hold

The signals are mixed – trend and MACD point in different directions. Wait until MACD crosses the zero line in the direction of the trend before acting.

Frequently Asked Questions About Axsome Therapeutics stock in 2026

Should you buy Axsome Therapeutics stock now?
The technical signal for Axsome Therapeutics is currently NEUTRAL. Axsome Therapeutics trades at $213.06 as of 8/6/2026. The overall technical signal is: Hold. The technical analysis shows the following: MACD is negative (bearish trend) at -5.874 with falling momentum (signal: -3.001); RSI is at 36.5 (neutral zone); the stock is in a short-term downtrend (price below the 20-day average); the analyst price target of $282.32 points to 32.5% upside. This is a technical observation based on current data, not investment advice.
What is the price target for Axsome Therapeutics stock?
The average analyst price target for Axsome Therapeutics is $282.32. The current price is $213.06, which gives an upside of 32.5%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $254.09 and $310.55.
Is Axsome Therapeutics a dividend stock?
No, Axsome Therapeutics does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Axsome Therapeutics stock?
Axsome Therapeutics is rated as a stock with moderate risk. the annual standard deviation is 42.9%, which classifies the stock as moderate risk.
Is Axsome Therapeutics overvalued?
No, Axsome Therapeutics is considered undervalued based on the analyst price target (32.5% upside). Axsome Therapeutics has the following valuation ratios: a P/S ratio of 15.4, a P/B ratio of 205.5. The analyst price target suggests that the stock is undervalued by 32.5%.
Is Axsome Therapeutics overbought?
No, Axsome Therapeutics is not overbought. RSI is at 36.5 (neutral zone). The technical indicators show: RSI is at 36.5 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 7.8% below the 20-day average (short-term downtrend). In addition, MACD is negative with falling momentum (bearish).
When is the next Axsome Therapeutics earnings report?
Axsome Therapeutics reports its next earnings on August 10, 2026. The stock currently trades at $213.06.
Is Axsome Therapeutics shorted?
Yes, Axsome Therapeutics is shorted with 9.2% of the free float sold short. This is a high level of short selling, which suggests some investors are betting on falling prices. Positive surprises can lead to a moderate short squeeze. Data is updated daily based on official filings with the SEC.
Are insiders buying Axsome Therapeutics stock?
No, insiders are not buying Axsome Therapeutics shares – they are net sellers. Over the last 3 months, insiders have made 0 purchases and 11 sales. On a net basis, 36,292,443 $ worth of shares were sold. Across the last 20 reported transactions, the split is 1 purchases and 19 sales, with a net 59,590,058 $ sold. Active sellers include TABUTEAU HERRIOT, JEFFS ROGER, Mahony Susan and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Axsome Therapeutics a good stock?
Based on our total score, Axsome Therapeutics is rated as a poor stock with a total score of 26 out of 100. The stock scores below average on value, quality and momentum – it sits at the lower end of the market. The score is made up of Value: 4/100, Quality: 14/100, Momentum: 59/100. In addition: analysts see 32.5% upside to the price target; technical signal: Hold. Whether Axsome Therapeutics is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Axsome Therapeutics stock?
The outlook for Axsome Therapeutics based on current data: the average analyst price target is $282.32 (+32.5%); the next earnings report is due on 8/10/2026, which can move the price. Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Axsome Therapeutics stock falling?
Axsome Therapeutics is falling right now. The technical indicators show: the price is 7.8% below the 20-day average; MACD is negative with falling momentum (bearish signal); short interest is 9.2% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis, insider section and news overview above.
How high can Axsome Therapeutics go?
The average analyst price target for Axsome Therapeutics is $282.32, which corresponds to a potential gain of 32.5% from the current price of $213.06. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Axsome Therapeutics fall?
We lack enough history to give a specific floor for Axsome Therapeutics. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Axsome Therapeutics do?
Axsome Therapeutics (AXSM) driver en biopharma-virksomhed, der udvikler og sælger nye behandlinger for lidelser i centralnervesystemet (CNS) i USA. De tjener penge på flere produkter, som allerede er på markedet. Blandt deres vigtigste produkter er Auvelity, som bruges mod sv... The company belongs to the Sundhed sector, more specifically the Bioteknologi industry, is headquartered in USA, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Axsome Therapeutics as an investment.
Did Axsome Therapeutics raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Axsome Therapeutics. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history and the news overview above.
Is Axsome Therapeutics making money or losing money?
No, Axsome Therapeutics is currently not making money — the company is losing money with a negative profit margin of -26.6%, a substantial loss. That means the business loses money on every dollar of revenue. For growth stocks investing in expansion this is normal — but it raises the risk if the company does not reach break-even before its capital runs out.
Can Axsome Therapeutics go bankrupt?
The bankruptcy risk of Axsome Therapeutics is rated as elevated. Altman Z2 (a model for assessing financial distress) is -6.30 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. The Piotroski score (financial health 0-9, higher is better) is 4 — which is average. Debt relative to equity is 897% (high). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Axsome Therapeutics have a lot of debt?
Yes, Axsome Therapeutics has elevated debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 897%. For the sundhed sector, anything above 150% counts as elevated — that raises the financial risk, especially if interest rates rise or earnings fall. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.