Axsome Therapeutics (AXSM.US) Price Target 2026/2027: 65% Upside – Rating and Stock Analysis

174.34
Price history for Axsome Therapeutics (AXSM.US) – stock price at $174.34, October 2026
Axsome Therapeutics stock price – price development 2026. Updated Oct 7, 2026.
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Axsome Therapeutics Price Target 2026: Analysts See 63% Upside

The average price target for Axsome Therapeutics is $284.63. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 63.26% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is Axsome Therapeutics overvalued or undervalued?

Axsome Therapeutics is currently undervalued with a gap of 63.3% relative to the price target.


The current price is $174.34, which places Axsome Therapeutics in the undervalued category. The stock is considered undervalued when the price is below $256.17, and overvalued when the price exceeds $313.09.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Axsome Therapeutics, the fair value range lies between $256.17 and $313.09.


See the full price target analysis for Axsome Therapeutics →

Analyst Ratings for Axsome Therapeutics stock in 2026: Strong Buy

22 analysts cover Axsome Therapeutics. There is broad agreement on a positive view — 95.4% recommend buying. The average price target is $284.63, which gives an upside of 63.3% from the current price.

Consensus: Strong Buy (4.77/5)
Strong Buy
18 (81.8%)
Buy
3 (13.6%)
Hold
1 (4.5%)
Strong Sell Sell Hold Buy Strong Buy
4.77 out of 5 based on 22 analysts

About Axsome Therapeutics – Biotechnology

Axsome Therapeutics (AXSM) is a biopharmaceutical company. It develops and sells medicines for brain and nervous system disorders. It makes money by selling products that are already approved and available to patients.

Its main products include:

- **Auvelity**, used to treat severe depression.
- **Sunosi**, which helps patients with narcolepsy or sleep apnea (a condition where breathing stops and starts during sleep) stay awake and alert during the day.
- **Symbravo**, a fast-acting treatment for migraine.

The company operates only in the United States. Its customers are patients and doctors within the US healthcare system.

Axsome is also working to get new drugs approved. One example is AXS-05, another treatment aimed at depression.

The company was founded in 2012.
Read more about the company

Key Figures for Axsome Therapeutics

$9.4B Market cap
$777M Revenue
Biotechnology Industry
- P/E
12.09 P/S
121.64 P/B
United States Listed on exchange
axsome.com Website

What kind of stock is Axsome Therapeutics?

Speculative stock

Axsome Therapeutics is classified as a speculative stock.

Score Overview for Axsome Therapeutics

💰 Value Score 5/100 (Very Low)
⭐ Quality Score 11/100 (Very Low)
🚀 Momentum Score 30/100 (Low)
📊 Total Score 15/100

⚠️ 5 red flags identified 4 critical

Our analysis has identified 5 potential risk factors in Axsome Therapeutics that investors should be aware of.

🚨 High debt: The debt-to-equity ratio is 897% – the company carries considerably more debt than equity, which raises the financial risk.
⚠️ Weak financial health: The Piotroski score is only 3/9 – the company shows signs of weakened profitability, liquidity or capital structure.
🚨 Weak balance sheet (elevated risk): Altman Z2 is -5.91 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative profit margin: The profit margin is -24.7% – the company is losing money on its operations.
🚨 Negative return on equity: ROE is -245.1% – the company is generating a negative return for shareholders.

📈 Valuation

The P/S ratio is 12.1 (high — the market pays a premium for the revenue). The P/B ratio is 121.6.

🏦 Financial Health

The Piotroski score is 3 out of 9 — weak financial health, be careful. Altman Z2 is -5.91 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 897.1% — high debt, which raises the risk.

🚀 Momentum & Short Interest

Short interest is 9.29% — elevated, some investors are betting on a decline.

Insider Trading in Axsome Therapeutics 2026: The Signal Is negative

In 2026, insiders at Axsome Therapeutics have made 20 transactions, all of which were sales. On a net basis, insiders took $62,491,060 out of the stock. Active insiders include Jacobson Mark L., TABUTEAU HERRIOT, JEFFS ROGER and others. In the short term (last 3 months), the insider signal is negative.

Short-Term Signal (3 months): Negative

Insiders have exclusively sold shares over the last 3 months.

Over the last 3 months: 0 purchases and 3 sales. A net $12,624,805 out of the stock.

Long-Term Signal (all transactions): Negative

Insiders have exclusively sold shares in the recent period. This can suggest management sees limited opportunity.

Across the last 20 transactions: 0 purchases and 20 sales. A net $62,491,060 out of the stock.

Latest sale: Jacobson Mark L. sold 10,000 shares at $208.65 each on 2026-09-03.

Who is selling: Jacobson Mark L., TABUTEAU HERRIOT, JEFFS ROGER, Mahony Susan, Coleman Mark and others.

Latest Insider Trades in Axsome Therapeutics (2026)

The table shows the last 20 reported insider transactions in Axsome Therapeutics. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-09-03 Jacobson Mark L. Sell 10,000 209 2,086,500
2026-08-06 TABUTEAU HERRIOT Sell 4,660 214 997,007
2026-08-05 TABUTEAU HERRIOT Sell 45,004 212 9,541,298
2026-07-01 TABUTEAU HERRIOT Sell 49,666 240 11,932,257
2026-06-11 JEFFS ROGER Sell 286 249 71,248
2026-06-10 Mahony Susan Sell 300 246 73,854
2026-06-10 JEFFS ROGER Sell 286 246 70,407
2026-06-10 Coleman Mark Sell 643 249 160,107
2026-06-09 TABUTEAU HERRIOT Sell 49,670 241 11,970,967
2026-06-09 Pizzie Nick Sell 33,000 240 7,922,970

Who is buying and selling Axsome Therapeutics shares in 2026?

The following insiders have sold shares: Jacobson Mark L., TABUTEAU HERRIOT, JEFFS ROGER, Mahony Susan, Coleman Mark and others. In total, $62,491,060 was sold across 20 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Axsome Therapeutics Short Selling 2026: 9.3% Sold Short

High short interest: 9.3% of the free float
Short % of free float
9.3%
Assessment
High short interest
Short squeeze risk
Moderate
Data source
EODHD
Reported about twice a month

Short interest over time: Axsome Therapeutics

0.0%5.8%11.6%
Peak 10.1% · 8/13
5/307/299/27
9.3% today (high)Peaked at 10.1% on Aug 13, 2026Last 30 days: −0.2 percentage pointsMeasured over 120 days
What does the trend tell you?
Short interest in Axsome Therapeutics has been fairly stable at 9.3% over the period. Neither many new short sellers have arrived nor many positions been closed.

What matters is when the curve starts to move. This is how shorting works: whoever shorts has borrowed the share and sold it, and to close the position again they must buy the share back. When short interest falls, shares are being bought back. So it is worth watching the trend, not just today's number.
The stock has a high share of short selling. Between 5-10% of the freely traded shares are sold short, which suggests some investors are betting on falling prices. Positive surprises can lead to a moderate short squeeze.

What does this mean for you as an investor?
A short interest of 9.3% means that 9.3% of the freely traded shares in Axsome Therapeutics have been borrowed and sold by investors betting on falling prices.

The next potential catalyst is the earnings report on Nov 2, 2026. With a short interest of 9.3%, the report can trigger considerable volatility.

Short interest comes from our data provider EODHD. The figure is reported about twice a month; we check it every trading day.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
▲
9.3%

When Does Axsome Therapeutics Report Earnings – Next Date: Nov 2, 2026

The next earnings report from Axsome Therapeutics is scheduled for November 2, 2026, before the market opens. This report covers the third quarter (Q3), which ended on September 30, 2026.



Technical Analysis of Axsome Therapeutics 2026 – Signal: Sell

Overall Technical Signal: Sell

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated October 7, 2026.

Technical analysis of Axsome Therapeutics (AXSM.US) – RSI 26, MACD negative (bearish), daily candlestick chart October 2026
Axsome Therapeutics technical analysis – candlestick chart with RSI, MACD and volume profile. Updated Oct 7, 2026.

Trend Analysis of Axsome Therapeutics, Inc

Axsome Therapeutics, Inc is in a short-term downtrend. The price of $174.34 is 12.1% below the 20-day average ($198.38). Medium term, the picture is negative: the price is 15.7% below the 50-day average ($206.86). Long term, the stock is 12.9% below the 200-day average ($200.07), which signals a long-term downtrend.

Golden Cross: The 50-day average (206.86) is above the 200-day average (200.07), which is a classic bullish signal for Axsome Therapeutics, Inc.

Is Axsome Therapeutics, Inc overbought or oversold?

Axsome Therapeutics, Inc has an RSI of 25.9, which places the stock in oversold territory (below 30). WARNING: Oversold in a downtrend is NOT a buy signal. When the trend is negative, RSI can stay oversold for a long time while the price keeps falling. Wait for a trend reversal before buying.

MACD Analysis for Axsome Therapeutics, Inc

Daily MACD: MACD is negative (-9.080), which means the short-term trend is bearish (the 12-day EMA is below the 26-day EMA). MACD is below the signal line (-6.658) by 2.422, which confirms growing negative momentum in the downtrend.

Weekly MACD: MACD5 is positive (1.247), which indicates a broader bullish long-term trend. MACD5 is below the signal line (9.492) by 8.245, which suggests the long-term momentum is fading – the positive trend could come under pressure.

Overall MACD assessment: The daily and weekly MACD give conflicting signals. The long-term trend is bullish, but the short-term trend is bearish. Short-term momentum is still falling – a deeper pullback is possible.

Risk Profile for Axsome Therapeutics, Inc

Axsome Therapeutics, Inc has an annual standard deviation of 43.8%, which classifies the stock as medium risk. The price can swing noticeably when the market moves.

Overall Technical Conclusion for Axsome Therapeutics, Inc

Trend: Negative. The price trades below SMA50 and SMA200.

MACD trend (zero line): Daily bearish (-9.080). Weekly bullish (1.247).

MACD momentum (signal): Daily falling. Weekly falling.

RSI: 25.9 – oversold.

Technical signal: Sell

The trend is negative and MACD is below the zero line, which confirms the bearish momentum. Consider reducing the position or setting a stop-loss.

Frequently Asked Questions About Axsome Therapeutics stock in 2026

Should you buy Axsome Therapeutics stock now?
No, the technical signal for Axsome Therapeutics is currently Sell. Axsome Therapeutics trades at $174.34 as of Oct 7, 2026. The technical analysis shows the following: MACD is negative (bearish trend) at -9.080 with falling momentum (signal: -6.658); RSI is at 25.9 (oversold), which could point to a potential buying opportunity; the stock is in a short-term downtrend (price below the 20-day average); the analyst price target of $284.63 points to 63.3% upside. The stock is in a broader downtrend (below SMA50/SMA200). Buying in a downtrend is generally not recommended. This is a technical observation based on current data, not investment advice.
What is the price target for Axsome Therapeutics stock?
The average analyst price target for Axsome Therapeutics is $284.63. The current price is $174.34, which gives an upside of 63.3%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $256.17 and $313.09.
Is Axsome Therapeutics a dividend stock?
No, Axsome Therapeutics does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Axsome Therapeutics stock?
Axsome Therapeutics is rated as a stock in the risk category Moderate. the annual standard deviation is 43.8%, which classifies the stock as Moderate. In addition, an RSI of 25.9 signals oversold (potential bottom).
Is Axsome Therapeutics overvalued?
No, Axsome Therapeutics is considered undervalued based on the analyst price target (63.3% upside). Axsome Therapeutics has the following valuation ratios: a P/S ratio of 12.1, a P/B ratio of 121.6. The analyst price target suggests that the stock is undervalued by 63.3%.
Is Axsome Therapeutics overbought?
No, Axsome Therapeutics is actually oversold with an RSI of 25.9 (below 30). The technical indicators show: RSI is at 25.9 (below the 30 mark), which actually signals the price is oversold – the opposite of overbought. In addition, the price is 12.1% below the 20-day average (short-term downtrend). In addition, MACD is negative with falling momentum (bearish). IMPORTANT: The stock is oversold in a downtrend. A low RSI in a downtrend is NOT a buy signal – the price can keep falling. Wait for a trend reversal before buying.
When is the next Axsome Therapeutics earnings report?
Axsome Therapeutics reports its next earnings on November 2, 2026. The stock currently trades at $174.34. The RSI is at 25.9, so the report can reinforce the current technical trend.
Is Axsome Therapeutics shorted?
Yes, Axsome Therapeutics is shorted with 9.3% of the free float sold short. This is a high level of short selling, which suggests some investors are betting on falling prices. Positive surprises can lead to a moderate short squeeze. The figure comes from our data provider EODHD, is reported about twice a month, and we check it every trading day.
Are insiders buying Axsome Therapeutics stock?
No, insiders are not buying Axsome Therapeutics shares – they are net sellers. Over the last 3 months, insiders have made 0 purchases and 3 sales. On a net basis, 12,624,805 $ worth of shares were sold. Across the last 20 reported transactions, the split is 0 purchases and 20 sales, with a net 62,491,060 $ sold. Active sellers include Jacobson Mark L., TABUTEAU HERRIOT, JEFFS ROGER and others. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Axsome Therapeutics a good stock?
Based on our total score, Axsome Therapeutics is rated as a disastrous stock with a total score of 15 out of 100. The stock scores very low on value, quality and momentum – it is among the worst in our database. The score is made up of Value: 5/100, Quality: 11/100, Momentum: 30/100. In addition: analysts see 63.3% upside to the price target; technical signal: Sell. Whether Axsome Therapeutics is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Axsome Therapeutics stock?
The outlook for Axsome Therapeutics based on current data: the average analyst price target is $284.63 (+63.3%); the stock is in a downtrend (below SMA50 and SMA200); the next earnings report is due on Nov 2, 2026, which can move the price. Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Axsome Therapeutics stock falling?
Axsome Therapeutics is falling right now. The technical indicators show: the price is 12.1% below the 20-day average; MACD is negative with falling momentum (bearish signal); short interest is 9.3% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis and insider section above.
How high can Axsome Therapeutics go?
The average analyst price target for Axsome Therapeutics is $284.63, which corresponds to a potential gain of 63.3% from the current price of $174.34. The stock has traded between $117.30 and $260.19 over the last 52 weeks. The price is 33.0% below the 52-week high, which can indicate potential if the underlying fundamentals are intact. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Axsome Therapeutics fall?
The stock has traded as low as $117.30 over the last 52 weeks — that is 32.7% below the current price of $174.34. The biggest decline (drawdown) in the same period was 54.9% from high to low. Within a year, the price typically swings about ±43.8% (standard deviation — a measure of price swings). A difficult year could therefore mean a further decline of that size. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Axsome Therapeutics do?
Axsome Therapeutics (AXSM) is a biopharmaceutical company. It develops and sells medicines for brain and nervous system disorders. It makes money by selling products that are already approved and available to patients. Its main products include: - **Auvelity**, used to treat... The company belongs to the Healthcare sector, more specifically the Biotechnology industry, is headquartered in United States, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Axsome Therapeutics as an investment.
Did Axsome Therapeutics raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Axsome Therapeutics. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history above.
Is Axsome Therapeutics making money or losing money?
No, Axsome Therapeutics is currently not making money — the company is losing money with a negative profit margin of -24.7%, a substantial loss. That means the business loses money on every dollar of revenue. For growth stocks investing in expansion this is normal — but it raises the risk if the company does not reach break-even before its capital runs out.
Can Axsome Therapeutics go bankrupt?
The bankruptcy risk of Axsome Therapeutics is rated as elevated. Altman Z2 (a model for assessing financial distress) is -5.91 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. The Piotroski score (financial health 0-9, higher is better) is 3 — which is weak. Debt relative to equity is 897% (high). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Axsome Therapeutics have a lot of debt?
Yes, Axsome Therapeutics has elevated debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 897%. For the healthcare sector, anything above 150% counts as elevated — that raises the financial risk, especially if interest rates rise or earnings fall. In healthcare, 80-150% is typical — large pharma companies carry debt for research and acquisitions. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.

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