Aptevo Therapeutics (APVO.US) Price Target 2026/2027: 990% Upside – Rating and Stock Analysis

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Price history for Aptevo Therapeutics (APVO.US) – stock price at 2.34 $, September 2026
Aptevo Therapeutics stock price – price development 2026. Updated Sep 2, 2026.
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Aptevo Therapeutics Price Target 2026: Analysts See 990% Upside

The average price target for Aptevo Therapeutics is $25.50. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 989.74% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is Aptevo Therapeutics overvalued or undervalued?

Aptevo Therapeutics is currently undervalued with a gap of 989.7% relative to the price target.


The current price is $2.34, which places Aptevo Therapeutics in the undervalued category. The stock is considered undervalued when the price is below $22.95, and overvalued when the price exceeds $28.05.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For Aptevo Therapeutics, the fair value range lies between $22.95 and $28.05.


See the full price target analysis for Aptevo Therapeutics →

Analyst Ratings for Aptevo Therapeutics stock in 2026: Buy

1 analysts cover Aptevo Therapeutics. There is broad agreement on a positive view — 100% recommend buying. The average price target is $25.50, which gives an upside of 989.7% from the current price.

Consensus: Buy (4.00/5)
Buy
1 (100%)
Strong Sell Sell Hold Buy Strong Buy
4.00 out of 5 based on 1 analysts

About Aptevo Therapeutics – Bioteknologi

Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. Its lead clinical blood cancer candidate is mipletamig that is in Phase 1b/2 clinical trial for the treatment of acute myelogenous leukemia. The company also develops ALG.APV-527, a novel investigational bispecific ADAPTIR candidate that is in Phase 1 clinical trial for the treatment malignant pleural mesothelioma, non-small cell lung, gastric/gastro-esophageal, head and neck squamous cell carcinoma, pancreatic, renal, ovarian, prostate, breast, cervical, colorectal, endometrial, and bladder cancers; APVO603, a preclinical dual agonist bispecific ADAPTIR candidate to treat multiple solid tumors; APVO442, a preclinical bispecific candidate based on the ADAPTIR-FLEX platform technology for the treatment of multiple solid tumors; and APVO711, a preclinical dual mechanism bispecific ADAPTIR candidate to treat prostate cancer. It has a collaboration and option agreement with Alligator Bioscience AB to develop ALG.APV-527. Aptevo Therapeutics Inc. was incorporated in 2016 and is headquartered in Seattle, Washington. Read more about the company

Key Figures for Aptevo Therapeutics

$ 4.4M Market cap
- Revenue
Bioteknologi Industry
0.01 P/E
2.70 P/S
0.72 P/B
USA Listed on exchange

What kind of stock is Aptevo Therapeutics?

Value stock

Aptevo Therapeutics is classified as a value stock with a value score in the top 100% of all stocks. The P/E ratio of 0.0 points to an attractive valuation.

Score Overview for Aptevo Therapeutics

⭐ Quality Score 3/100 (Very Low)
📊 Total Score 1/100

⚠️ 4 red flags identified 2 critical

Our analysis has identified 4 potential risk factors in Aptevo Therapeutics that investors should be aware of.

⚠️ High debt: The debt-to-equity ratio is 228% – the company carries considerably more debt than equity, which raises the financial risk.
⚠️ Weak financial health: The Piotroski score is only 2/9 – the company shows signs of weakened profitability, liquidity or capital structure.
🚨 Weak balance sheet (elevated risk): Altman Z2 is -73.59 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative return on equity: ROE is -420.3% – the company is generating a negative return for shareholders.

📈 Valuation

Aptevo Therapeutics trades at a P/E ratio of 0.0, which is below the market average and can point to an attractive price. The forward P/E is 3.9. The P/S ratio is 2.7. The P/B ratio is 0.7, below book value, which can point to a value opportunity.

🏦 Financial Health

The Piotroski score is 2 out of 9 — weak financial health, be careful. Altman Z2 is -73.59 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 227.9% — high debt, which raises the risk.

🚀 Momentum & Short Interest

Short interest is 4.54%.

Insider Trading in Aptevo Therapeutics 2026: The Signal Is negative

In 2026, insiders at Aptevo Therapeutics have made 7 transactions – split into 1 purchases and 6 sales. On a net basis, insiders took 2,225,942 $ out of the stock. Active insiders include Grant Grady III, White Marvin L, Huebner Dirk and others. In the short term (last 3 months), the insider signal is negative.

Short-Term Signal (3 months): Negative

Insiders have exclusively sold shares over the last 3 months.

Over the last 3 months: 0 purchases and 2 sales. A net 9,377 $ out of the stock.

Long-Term Signal (all transactions): Mostly negative

Insiders have sold considerably more than they have bought. At large companies this can be due to planned sales (10b5-1 plans) and is not necessarily a negative signal.

Across the last 7 transactions: 1 purchases and 6 sales. A net 2,225,942 $ out of the stock.

Latest purchase: Grant Grady III bought 13,513 shares at 1 $ each on 2025-11-10. The stock has since risen 57%.

Latest sale: White Marvin L sold 1,666 shares at 4 $ each on 2026-08-06.

Who is buying: Grant Grady III.

Who is selling: White Marvin L, Huebner Dirk, TANG KEVIN C.

Latest Insider Trades in Aptevo Therapeutics (2026)

The table shows the last 7 reported insider transactions in Aptevo Therapeutics. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-08-06 White Marvin L Sell 1,666 4 6,781
2026-08-06 Huebner Dirk Sell 638 4 2,597
2025-11-10 Grant Grady III Buy 13,513 1 20,134
2021-11-23 TANG KEVIN C Sell 161,336 10 1,548,826
2021-11-22 TANG KEVIN C Sell 16,667 7 109,169
2021-11-19 TANG KEVIN C Sell 30,467 8 229,112
2021-11-18 TANG KEVIN C Sell 43,213 8 349,593

Who is buying and selling Aptevo Therapeutics shares in 2026?

The following insiders have bought shares in Aptevo Therapeutics: Grant Grady III. In total, 20,134 $ was bought across 1 transactions. The following insiders have sold shares: White Marvin L, Huebner Dirk, TANG KEVIN C. In total, 2,246,077 $ was sold across 6 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

Aptevo Therapeutics Short Selling 2026: 4.5% Sold Short

Moderate short interest: 4.5% of the free float
Short % of free float
4.5%
Assessment
Moderate short interest
Short squeeze risk
Low
Data source
SEC
Updated daily
The stock has a moderate share of short selling. Between 2-5% of the freely traded shares are sold short, which is within the normal range for most stocks.

Data is updated daily based on official filings with the SEC.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
4.5%

When Does Aptevo Therapeutics Report Earnings?

The next earnings date for Aptevo Therapeutics is not yet available. Check the company's investor calendar for more information.



Technical Analysis of Aptevo Therapeutics 2026 – Signal: Strong Sell

Overall Technical Signal: Strong Sell

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated September 2, 2026.

Technical analysis of Aptevo Therapeutics (APVO.US) – RSI 25, MACD negative (bearish), daily candlestick chart September 2026
Aptevo Therapeutics technical analysis – candlestick chart with RSI, MACD and volume profile. Updated Sep 2, 2026.

Trend Analysis of Aptevo Therapeutics Inc

Aptevo Therapeutics Inc is in a short-term downtrend. The price of $2.34 is 23.5% below the 20-day average ($3.06). Medium term, the picture is negative: the price is 39.2% below the 50-day average ($3.85). Long term, the stock is 69.9% below the 200-day average ($7.76), which signals a long-term downtrend.

Death Cross: The 50-day average (3.85) is below the 200-day average (7.76), which is a classic bearish signal for Aptevo Therapeutics Inc.

Is Aptevo Therapeutics Inc overbought or oversold?

Aptevo Therapeutics Inc has an RSI of 24.8, which places the stock in oversold territory (below 30). WARNING: Oversold in a downtrend is NOT a buy signal. When the trend is negative, RSI can stay oversold for a long time while the price keeps falling. Wait for a trend reversal before buying.

MACD Analysis for Aptevo Therapeutics Inc

Daily MACD: MACD is negative (-0.479), which means the short-term trend is bearish (the 12-day EMA is below the 26-day EMA). MACD is below the signal line (-0.453) by 0.026, which confirms growing negative momentum in the downtrend.

Weekly MACD: MACD5 is negative (-26.864), which indicates a broader bearish long-term trend. MACD5 is above the signal line (-40.038) by 13.174, which suggests the negative long-term momentum is fading – a bigger trend reversal could be ahead.

Overall MACD assessment: Both the daily and weekly trend are bearish (MACD negative). However, momentum shows signs of improving on a weekly basis – a potential trend reversal could be ahead, but it is not confirmed yet.

Risk Profile for Aptevo Therapeutics Inc

Aptevo Therapeutics Inc has an annual standard deviation of 98.6%, which classifies the stock as Extremely speculative. Only risk-tolerant investors should consider this stock, because the price swings can be very large.

Overall Technical Conclusion for Aptevo Therapeutics Inc

Trend: Negative. The price trades below SMA50 and SMA200.

MACD trend (zero line): Daily bearish (-0.479). Weekly bearish (-26.864).

MACD momentum (signal): Daily falling. Weekly rising.

RSI: 24.8 – oversold.

Technical signal: Strong Sell

The price is in a downtrend (below SMA50/SMA200) and MACD is negative on both a daily and weekly basis. Avoid buying and consider closing existing positions.

Frequently Asked Questions About Aptevo Therapeutics stock in 2026

Should you buy Aptevo Therapeutics stock now?
No, the technical signal for Aptevo Therapeutics is currently SELL. Aptevo Therapeutics trades at $2.34 as of 9/2/2026. The overall technical signal is: Strong Sell. The technical analysis shows the following: MACD is negative (bearish trend) at -0.479 with falling momentum (signal: -0.453); RSI is at 24.8 (oversold), which could point to a potential buying opportunity; the stock is in a short-term downtrend (price below the 20-day average); the analyst price target of $25.50 points to 989.7% upside. The stock is in a broader downtrend (below SMA50/SMA200). Buying in a downtrend is generally not recommended. This is a technical observation based on current data, not investment advice.
What is the price target for Aptevo Therapeutics stock?
The average analyst price target for Aptevo Therapeutics is $25.50. The current price is $2.34, which gives an upside of 989.7%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $22.95 and $28.05.
Is Aptevo Therapeutics a dividend stock?
No, Aptevo Therapeutics does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of Aptevo Therapeutics stock?
Aptevo Therapeutics is rated as a stock in the risk category Extremely speculative. the annual standard deviation is 98.6%, which classifies the stock as Extremely speculative. In addition, an RSI of 24.8 signals oversold (potential bottom).
Is Aptevo Therapeutics overvalued?
No, Aptevo Therapeutics is considered undervalued based on the analyst price target (989.7% upside). Aptevo Therapeutics has the following valuation ratios: a P/E ratio of 0.0 (lowly valued), a P/S ratio of 2.7, a P/B ratio of 0.7. The analyst price target suggests that the stock is undervalued by 989.7%.
Is Aptevo Therapeutics overbought?
No, Aptevo Therapeutics is actually oversold with an RSI of 24.8 (below 30). The technical indicators show: RSI is at 24.8 (below the 30 mark), which actually signals the price is oversold – the opposite of overbought. In addition, the price is 23.5% below the 20-day average (short-term downtrend). In addition, MACD is negative with falling momentum (bearish). IMPORTANT: The stock is oversold in a downtrend. A low RSI in a downtrend is NOT a buy signal – the price can keep falling. Wait for a trend reversal before buying.
When is the next Aptevo Therapeutics earnings report?
The date of the next earnings report for Aptevo Therapeutics has not been published yet. Check the company's investor calendar for updates.
Is Aptevo Therapeutics shorted?
Yes, Aptevo Therapeutics is shorted with 4.5% of the free float sold short. This is a moderate level of short selling, within the normal range for most stocks. Data is updated daily based on official filings with the SEC.
Are insiders buying Aptevo Therapeutics stock?
No, insiders are not buying Aptevo Therapeutics shares – they are net sellers. Over the last 3 months, insiders have made 0 purchases and 2 sales. On a net basis, 9,377 $ worth of shares were sold. Across the last 7 reported transactions, the split is 1 purchases and 6 sales, with a net 2,225,942 $ sold. Active sellers include White Marvin L, Huebner Dirk, TANG KEVIN C. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is Aptevo Therapeutics a good stock?
Based on our total score, Aptevo Therapeutics is rated as a disastrous stock with a total score of 3 out of 100. The stock scores very low on value, quality and momentum – it is among the worst in our database. The score is made up of Quality: 3/100. In addition: analysts see 989.7% upside to the price target; technical signal: Strong Sell. Whether Aptevo Therapeutics is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for Aptevo Therapeutics stock?
The outlook for Aptevo Therapeutics based on current data: the average analyst price target is $25.50 (+989.7%); the stock is in a downtrend (below SMA50 and SMA200); the P/E ratio is 0.0 (low – a possible value stock). Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is Aptevo Therapeutics stock falling?
Aptevo Therapeutics is falling right now. The technical indicators show: the price is 23.5% below the 20-day average; MACD is negative with falling momentum (bearish signal); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis, insider section and news overview above.
How high can Aptevo Therapeutics go?
The average analyst price target for Aptevo Therapeutics is $25.50, which corresponds to a potential gain of 989.7% from the current price of $2.34. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can Aptevo Therapeutics fall?
We lack enough history to give a specific floor for Aptevo Therapeutics. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does Aptevo Therapeutics do?
Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX pla... The company belongs to the Healthcare sector, more specifically the Bioteknologi industry, is headquartered in USA, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate Aptevo Therapeutics as an investment.
Did Aptevo Therapeutics raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from Aptevo Therapeutics. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history and the news overview above.
Is Aptevo Therapeutics making money or losing money?
We have no current profitability data for Aptevo Therapeutics. See the latest report in the earnings history above.
Can Aptevo Therapeutics go bankrupt?
The bankruptcy risk of Aptevo Therapeutics is rated as elevated. Altman Z2 (a model for assessing financial distress) is -73.59 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. The Piotroski score (financial health 0-9, higher is better) is 2 — which is weak. Debt relative to equity is 228% (high). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does Aptevo Therapeutics have a lot of debt?
Yes, Aptevo Therapeutics has elevated debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 228%. For the healthcare sector, anything above 150% counts as elevated — that raises the financial risk, especially if interest rates rise or earnings fall. In healthcare, 80-150% is typical — large pharma companies carry debt for research and acquisitions. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.