AC Immune (ACIU.US) Price Target 2026/2027: 205% Upside – Rating and Stock Analysis

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AC Immune Price Target 2026: Analysts See 206% Upside

The average price target for AC Immune is $8.50. This price target represents the analysts' view of the stock price over the next 12 months. The stock may be undervalued, because the price target is higher than the current price. The stock is 205.76% below the target, which can point to potential returns within the next 12 months if the analysts' view proves right. Also consider the stock's valuation ratios such as P/E, P/S and P/B, plus the technical analysis further down the page, for the full picture.

Is AC Immune overvalued or undervalued?

AC Immune is currently undervalued with a gap of 205.8% relative to the price target.


The current price is $2.78, which places AC Immune in the undervalued category. The stock is considered undervalued when the price is below $7.65, and overvalued when the price exceeds $9.35.


The fair value range is defined as ±10% of the price target, because price targets are estimates rather than exact values. For AC Immune, the fair value range lies between $7.65 and $9.35.


See the full price target analysis for AC Immune →

Analyst Ratings for AC Immune stock in 2026: Strong Buy

4 analysts cover AC Immune. There is broad agreement on a positive view — 100% recommend buying. The average price target is $8.50, which gives an upside of 205.8% from the current price.

Consensus: Strong Buy (4.75/5)
Strong Buy
3 (75%)
Buy
1 (25%)
Strong Sell Sell Hold Buy Strong Buy
4.75 out of 5 based on 4 analysts

About AC Immune – Biotechnology

AC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines, and therapeutic and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. The company's SupraAntigen and Morphomer platforms are designed to generate biologics and small molecules, which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. It develops Crenezumab, a humanized, conformation specific monoclonal antibody used to slow Alzheimer's disease (AD) progression; and Semorinemab, an investigational monoclonal anti-Tau antibody that targets the N-terminal portion of the Tau protein and is designed to bind to Tau and slow its spread between neurons for the treatment of AD. The company is also developing ACI-24.060 for the treatment of down syndrome related AD; ACI-7104.056 to treat Parkinson's disease; and ACI-35.030, designs to stimulate a patient's immune system to produce antibodies against pathological phosphorylated Tau. In addition, it develops diagnostic programs consisting of PI-2620, a Tau diagnostic for AD, as well as non-AD Tauopathies; and ACI-12589 and ACI-15916, a-sync PET tracer that supports the differential diagnosis of multiple system atrophy from other neurodegenerative diseases. Further, the company is researching and developing Morphomer Tau aggregation inhibitors to evaluate candidates in AD; Morphomer a-syn to compete with small molecule inhibitors of a-syn aggregation; and NeuroOrphan Tauopathies. Additionally, it generates discovery and preclinical stage molecules targeting range of neurodegenerative diseases, which include diagnostics targeting TDP-43, alpha-synuclein, and NLRP3. The company has license agreements and collaborations with Genentech, Inc.; Janssen Pharmaceuticals, Inc.; Life Molecular Imaging SA; and Eli Lilly and Company. AC Immune SA was incorporated in 2003 and is headquartered in Lausanne, Switzerland. Read more about the company

Key Figures for AC Immune

$ 284M Market cap
$ 17.5M Revenue
Biotechnology Industry
- P/E
16.24 P/S
6.74 P/B
USA Listed on exchange

What kind of stock is AC Immune?

Speculative stock

AC Immune is classified as a speculative stock.

Score Overview for AC Immune

💰 Value Score 9/100 (Very Low)
⭐ Quality Score 1/100 (Very Low)
🚀 Momentum Score 37/100 (Low)
📊 Total Score 15/100

⚠️ 4 red flags identified 3 critical

Our analysis has identified 4 potential risk factors in AC Immune that investors should be aware of.

⚠️ Weak financial health: The Piotroski score is only 3/9 – the company shows signs of weakened profitability, liquidity or capital structure.
🚨 Weak balance sheet (elevated risk): Altman Z2 is -12.88 – the balance sheet is measurably weaker than average. This is a risk signal based on the numbers, not a bankruptcy prediction.
🚨 Negative profit margin: The profit margin is -246.5% – the company is losing money on its operations.
🚨 Negative return on equity: ROE is -78.5% – the company is generating a negative return for shareholders.

📈 Valuation

The P/S ratio is 16.2 (high — the market pays a premium for the revenue). The P/B ratio is 6.7.

💵 Profitability & Growth

AC Immune and an operating margin of 7.9%.

🏦 Financial Health

The Piotroski score is 3 out of 9 — weak financial health, be careful. Altman Z2 is -12.88 (weak balance sheet — elevated risk). The debt-to-equity ratio (D/E) is 105.7% — moderate debt.

🚀 Momentum & Short Interest

Short interest is 7.33% — elevated, some investors are betting on a decline.

Insider Trading in AC Immune 2026: The Signal Is negative

In 2026, insiders at AC Immune have made 2 transactions, all of which were sales. On a net basis, insiders took 59,300 $ out of the stock. Active insiders include Pfeifer Andrea.

Short-Term Signal (3 months): No activity

There has been no insider trading in the last 3 months.

Long-Term Signal (all transactions): Negative

Insiders have exclusively sold shares in the recent period. This can suggest management sees limited opportunity.

Across the last 2 transactions: 0 purchases and 2 sales. A net 59,300 $ out of the stock.

Latest sale: Pfeifer Andrea sold 10,000 shares at 3 $ each on 2026-05-15.

Who is selling: Pfeifer Andrea.

Latest Insider Trades in AC Immune (2026)

The table shows the last 2 reported insider transactions in AC Immune. Green rows are purchases, red rows are sales. The data is based on official filings.

Transaction date Name Type Number of shares Price per share ($) Total amount ($)
2026-05-15 Pfeifer Andrea Sell 10,000 3 27,900
2026-04-15 Pfeifer Andrea Sell 10,000 3 31,400

Who is buying and selling AC Immune shares in 2026?

The following insiders have sold shares: Pfeifer Andrea. In total, 59,300 $ was sold across 2 transactions. Insider trades are legal transactions in which executives and board members buy or sell shares of their own company. These transactions are reported to the SEC and are publicly available.

AC Immune Short Selling 2026: 7.3% Sold Short

High short interest: 7.3% of the free float
Short % of free float
7.3%
Assessment
High short interest
Short squeeze risk
Moderate
Data source
SEC
Updated daily
The stock has a high share of short selling. Between 5-10% of the freely traded shares are sold short, which suggests some investors are betting on falling prices. Positive surprises can lead to a moderate short squeeze.

What does this mean for you as an investor?
A short interest of 7.3% means that 7.3% of the freely traded shares in AC Immune have been borrowed and sold by investors betting on falling prices.

Data is updated daily based on official filings with the SEC.
Short Interest Scale
0% 2% 5% 10% 20%+
Low Moderate High Very High Extreme
7.3%

When Does AC Immune Report Earnings?

The next earnings date for AC Immune is not yet available. Check the company's investor calendar for more information.



Technical Analysis of AC Immune 2026 – Signal: Hold

Overall Technical Signal: Hold

Based on trend analysis (SMA50/SMA200) and MACD trend (positive/negative on a daily + weekly basis). Updated September 9, 2026.

Trend Analysis of AC Immune SA

AC Immune SA is in a short-term uptrend. The price of $2.78 is 2.7% above the 20-day average ($2.71). Medium term, the picture is positive: the price is 11.4% above the 50-day average ($2.50). Long term, the stock is 1.9% below the 200-day average ($2.84), which signals a long-term downtrend.

Death Cross: The 50-day average (2.50) is below the 200-day average (2.84), which is a classic bearish signal for AC Immune SA.

Is AC Immune SA overbought or oversold?

AC Immune SA has an RSI of 56.4. The stock shows positive momentum in the upper part of the neutral zone.

MACD Analysis for AC Immune SA

Daily MACD: MACD is positive (0.103), which means the short-term trend is bullish (the 12-day EMA is above the 26-day EMA). MACD is above the signal line (0.100) by 0.003, which confirms rising momentum in the uptrend.

Weekly MACD: MACD5 is negative (-0.064), which indicates a broader bearish long-term trend. MACD5 is above the signal line (-0.116) by 0.052, which suggests the negative long-term momentum is fading – a bigger trend reversal could be ahead.

Overall MACD assessment: The daily and weekly MACD give conflicting signals. The short-term trend is bullish, but the long-term trend is still bearish. Weekly momentum is rising, though, which could signal an upcoming trend reversal.

Risk Profile for AC Immune SA

AC Immune SA has an annual standard deviation of 76.3%, which classifies the stock as Extremely speculative. Only risk-tolerant investors should consider this stock, because the price swings can be very large.

Overall Technical Conclusion for AC Immune SA

Trend: Neutral/mixed.

MACD trend (zero line): Daily bullish (0.103). Weekly bearish (-0.064).

MACD momentum (signal): Daily rising. Weekly rising.

RSI: 56.4 – neutral.

Technical signal: Hold

The signals are mixed – trend and MACD point in different directions. Wait until MACD crosses the zero line in the direction of the trend before acting.

Frequently Asked Questions About AC Immune stock in 2026

Should you buy AC Immune stock now?
The technical signal for AC Immune is currently NEUTRAL. AC Immune trades at $2.78 as of 9/9/2026. The overall technical signal is: Hold. The technical analysis shows the following: MACD is positive (bullish trend) at 0.103 with rising momentum (signal: 0.100); RSI is at 56.4 (neutral zone); the stock is in a short-term uptrend (price above the 20-day average); the analyst price target of $8.50 points to 205.8% upside. This is a technical observation based on current data, not investment advice.
What is the price target for AC Immune stock?
The average analyst price target for AC Immune is $8.50. The current price is $2.78, which gives an upside of 205.8%. Based on this, the stock is considered undervalued. The fair value range (±10% of the price target) is between $7.65 and $9.35.
Is AC Immune a dividend stock?
No, AC Immune does not currently pay a dividend to shareholders. The company reinvests its profits in growth instead of paying dividends.
What is the risk of AC Immune stock?
AC Immune is rated as a stock in the risk category Extremely speculative. the annual standard deviation is 76.3%, which classifies the stock as Extremely speculative.
Is AC Immune overvalued?
No, AC Immune is considered undervalued based on the analyst price target (205.8% upside). AC Immune has the following valuation ratios: a P/S ratio of 16.2, a P/B ratio of 6.7. The analyst price target suggests that the stock is undervalued by 205.8%.
Is AC Immune overbought?
No, AC Immune is not overbought. RSI is at 56.4 (neutral zone). The technical indicators show: RSI is at 56.4 (neutral zone between 30-70), which signals neither overbought nor oversold. In addition, the price is 2.7% above the 20-day average (short-term uptrend). In addition, MACD is positive with rising momentum (bullish).
When is the next AC Immune earnings report?
The date of the next earnings report for AC Immune has not been published yet. Check the company's investor calendar for updates.
Is AC Immune shorted?
Yes, AC Immune is shorted with 7.3% of the free float sold short. This is a high level of short selling, which suggests some investors are betting on falling prices. Positive surprises can lead to a moderate short squeeze. Data is updated daily based on official filings with the SEC.
Are insiders buying AC Immune stock?
No, insiders are not buying AC Immune shares – they are net sellers. Across the last 2 reported transactions, the split is 0 purchases and 2 sales, with a net 59,300 $ sold. Active sellers include Pfeifer Andrea. Insider selling can have several explanations (e.g. planned 10b5-1 sales, portfolio diversification or taxes), but sustained selling by several insiders is worth watching closely.
Is AC Immune a good stock?
Based on our total score, AC Immune is rated as a disastrous stock with a total score of 16 out of 100. The stock scores very low on value, quality and momentum – it is among the worst in our database. The score is made up of Value: 9/100, Quality: 1/100, Momentum: 37/100. In addition: analysts see 205.8% upside to the price target; technical signal: Hold. Whether AC Immune is a good investment depends on your time horizon, risk profile and portfolio. This is a data-driven observation, not investment advice.
What is the outlook for AC Immune stock?
The outlook for AC Immune based on current data: the average analyst price target is $8.50 (+205.8%). Keep in mind that stock prices are affected by many factors, including earnings reports, the economy and market sentiment. Past returns are no guarantee of future returns.
Why is AC Immune stock rising?
AC Immune is rising right now. The technical indicators show: the price is 2.7% above the 20-day average; MACD is positive with rising momentum (bullish signal); short interest is 7.3% (high – many are betting on a decline); insiders have mostly been selling the stock recently. For the latest context, see our technical analysis, insider section and news overview above.
How high can AC Immune go?
The average analyst price target for AC Immune is $8.50, which corresponds to a potential gain of 205.8% from the current price of $2.78. Keep in mind that price targets are estimates, not guarantees. Actual price moves depend on earnings, market conditions and unexpected events.
How low can AC Immune fall?
We lack enough history to give a specific floor for AC Immune. Remember: past price swings are no guarantee for the future — a stock can fall further than the last 52 weeks suggest, especially on profit warnings, sector crises or a market crash. Use stop-loss orders and spread your portfolio to limit losses in single stocks.
What does AC Immune do?
AC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines, and therapeutic and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. The company's SupraAntigen and Morph... The company belongs to the Healthcare sector, more specifically the Biotechnology industry, is headquartered in USA, and is traded on the USA Stocks. See the key figures, earnings history and price development above to evaluate AC Immune as an investment.
Did AC Immune raise or lower its guidance?
Over the last 60 days we have not registered a guidance raise or cut from AC Immune. The company can still adjust its guidance at quarterly reports or between reports — see the earnings history and the news overview above.
Is AC Immune making money or losing money?
No, AC Immune is currently not making money — the company is losing money with a negative profit margin of -246.5%, a substantial loss. That means the business loses money on every dollar of revenue. The operating margin, however, is positive at 7.9% — the core business makes money; the loss comes from financing costs, taxes or one-off items. For growth stocks investing in expansion this is normal — but it raises the risk if the company does not reach break-even before its capital runs out.
Can AC Immune go bankrupt?
The bankruptcy risk of AC Immune is rated as elevated. Altman Z2 (a model for assessing financial distress) is -12.88 — that places the company in the weak zone. This is a probability based on the numbers, not a verdict — bankruptcy is not imminent. But the balance sheet is measurably weaker than average, so watch the debt, liquidity and possible capital raises. The Piotroski score (financial health 0-9, higher is better) is 3 — which is weak. Debt relative to equity is 106% (moderate). Remember: models like Altman Z2 are statistical — unexpected shocks (fraud, a sector collapse, lawsuits) can always happen. Spread your portfolio.
Does AC Immune have a lot of debt?
AC Immune has moderate debt relative to equity. The debt-to-equity ratio (D/E — interest-bearing debt to equity) is 106%. For the healthcare sector, 80-150% counts as a typical level. In healthcare, 80-150% is typical — large pharma companies carry debt for research and acquisitions. Note: D/E levels are highly sector-specific — a bank at 300% debt is normal, a tech stock at 300% is extremely leveraged. Always compare with similar companies in the same sector.

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